February 12, 2010
Haskal ZJ, Trerotola S, Dolmatch B, Schuman E, Altman S, Mietling S, Berman S, McLennan G, Trimmer C, Ross J, Vesely T. N Engl J Med. 2010 Feb 11;362(6):494-503
This important RCT concludes that in treatment of venous anastomotic stenosis of hemodialysis grafts, angioplasty plus placement of a stent provides better longer-term patency and freedom from repeat interventions than balloon angioplasty.
February 12, 2010
Wolf M. Clin J Am Soc Nephrol. 2010 Jan;5(1):1-3
In this succinct editorial, Dr. Wolf reinforces the rationale for performing proper randomized controlled trials in bone mineral metabolism before changing clinical practice. In addition, he provides insight into a first-in-class substudy of the ACHIEVE study which looks at the effects of cinacalcet and activated Vitamin D on FGF23 levels in ESRD.
Free full text kindly [...]
February 12, 2010
Mak RH, Flynn J, Bakris G. Nat Rev Nephrol. 2010 Feb;6(2):67-8
This review summarizes results of the landmark ESCAPE trial, which has shown that lowering the blood pressure target to below the 50th percentile slows pediatric chronic kidney disease progression.
February 12, 2010
Szczech LA, Barnhart HX, Sapp S, Felker GM, Hernandez A, Reddan D, Califf RM, Inrig JK, Patel UD, Singh AK. Kidney Int. 2010 Feb;77(3):239-46
This interesting secondary analysis of the CHOIR trial demonstrates that patients achieving their assigned Hb target had better outcomes than those that did not achieve target. Furthermore, those patients randomized to a higher Hb target, who actually reached that target, saw no increased risk. This study raises the question whether it is the high dose [...]
February 12, 2010
Perazella MA. Am J Kidney Dis. 2010 Feb;55(2):399-409
This addition to the AJKD Core Curriculum series reviews “Toxic Nephropathies”.
February 12, 2010
Shurraw S, Tonelli M. Am J Kidney Dis. 2010 Feb;55(2):237-40
This review discusses the role of statins in dialysis patients and offers insight into the interpretation of AURORA and the 4D study.
February 12, 2010
Pop-Busui R, Roberts L, Pennathur S, Kretzler M, Brosius FC, Feldman EL. Am J Kidney Dis. 2010 Feb;55(2):365-85
This indepth review looks at diabetic autonomic and peripheral neuropathy in patients with stages 4-5 CKD or ESRD undergoing dialysis. The evidence supporting the available therapeutic options and the challenges associated with providing adequate care as well as future directions for investigation are discussed.
February 12, 2010
Hoorn EJ, Zietse R. NDT Plus. 2010 Feb;3(1):42-44
February 12, 2010
Höcker B, Weber LT, Feneberg R, Drube J, John U, Fehrenbach H, Pohl M, Zimmering M, Fründ S, Klaus G, Wühl E, Tönshoff B. Nephrol Dial Transplant. 2010 Feb;25(2):617-24
Along with usual side effects of steroids is the impact on growth in pediatric patients. In this RCT, renal transplant recipients at least one year post-transplant were randomized to steroid continuation or withdrawal. Longitudinal growth was greater in the steroid withdrawal group. There were also improvements in blood pressure and HbA1c, with no graft losses [...]
February 12, 2010
Naqvi R, Naqvi A, Akhtar S, Ahmed E, Noor H, Saeed T, Akhtar F, Rizvi A. Nephrol Dial Transplant. 2010 Feb;25(2):634-7
Reactivation of tuberculosis post-transplant is a significant concern in countries where TB is endemic. This study randomized living-donor recipients to INH or not. Prophylaxis with INH significantly reduced the incidence of TB post-transplant, with very little hepatotoxicity.
February 12, 2010
Parekh J, Bostrom A, Feng S. Am J Transplant. 2010 Jan 6;
This paired kidney analysis compared results of a transplantation where one recipient was diabetic and the other was not. In uni- and multivariate analyses, diabetes was associated with a significantly higher risk for DGF. The risk appeared to be greater in women rather than men. Whether the risk of diabetes is due to hyperglycemia itself [...]
February 12, 2010
Gill JS, Landsberg D, Johnston O, Shapiro RJ, Magil AB, Wu V, Tinckam K, Keown P. Transplantation. 2010 Jan 27;89(2):178-84
Several studies have shown the development of anti-donor HLA-antibodies after transplantation is a risk factor for graft loss, suggesting that antibodies should be monitored to identify patients at risk of immunologic events. In this study, patients were prospectively studied for the development of antibodies during the first year post-transplant. Anti-HLA antibodies developed at the same [...]
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