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This newsletter is supported through unrestricted funding provided by Genzyme Corporation.

Welcome to Nephrology Now, a monthly list of the most pertinent and/or potentionally controversial articles in clinical Nephrology. These articles are selected from a wide range of journals from throughout the Nephrology and Internal Medicine literature. We also include a selection of review articles, opinion pieces and cases that may be of interest.

Nephrology Now: an Online Journal Club
Join others from around the world to discuss articles mentioned in each issue of Nephrology Now. This month's article for discussion is the Intensity of Renal Support in Critically Ill Patients with Acute Kidney Injury. N Engl J Med. 2008 May 20. Click here to join in...

Original Research - General Nephrology

Cooper CJ et al.
Embolic protection and platelet inhibition during renal artery stenting.
Circulation. 2008 May 27;117(21):2752-60. [Free Abstract] [Full Text]

Accompanying Editorial
Bittl JA et al.
Damage control for renal artery stenting.
Circulation. 2008 May 27;117(21):2724-6. [Full Text]


Côté AM et al.
Diagnostic accuracy of urinary spot protein: creatinine ratio for proteinuria in hypertensive pregnant women: systematic review.
BMJ. 2008 May 3;336(7651):1003-6. [Free Full Text]

Dember LM et al.
Effect of clopidogrel on early failure of arteriovenous fistulas for hemodialysis: a randomized controlled trial.
JAMA. 2008 May 14;299(18):2164-71. [Free Abstract] [Full Text]

Accompanying Editorial
Tonelli M.
Randomized trials in hemodialysis patients: time to step up to the plate.
JAMA. 2008 May 14;299(18):2205-7. [Free Extract] [Full Text]


DREAM Trial Investigator.
Effects of ramipril and rosiglitazone on cardiovascular and renal outcomes in people with impaired glucose tolerance or impaired fasting glucose: results of the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) trial.
Diabetes Care. 2008 May;31(5):1007-14. [Free Abstract] [Full Text]

Janssens HJ et al.
Use of oral prednisolone or naproxen for the treatment of gout arthritis: a double-blind, randomised equivalence trial.
Lancet. 2008 May 31;371(9627):1854-60. [Free Abstract] [Full Text]

Navaneethan SD et al.
A systematic review of patient and health system characteristics associated with late referral in chronic kidney disease.
BMC Nephrol. 2008 Feb 25;9:3. [Free Full Text]

Nickolas TL et al.
Sensitivity and specificity of a single emergency department measurement of urinary neutrophil gelatinase-associated lipocalin for diagnosing acute kidney injury.
Ann Intern Med. 2008 Jun 3;148(11):810-9. [Free Abstract] [Full Text]

Parienti JJ et al .
Femoral vs jugular venous catheterization and risk of nosocomial events in adults requiring acute renal replacement therapy: a randomized controlled trial.
JAMA. 2008 May 28;299(20):2413-22. [Free Abstract] [Full Text]

Parving HH et al.
Aliskiren combined with losartan in type 2 diabetes and nephropathy.
N Engl J Med. 2008 Jun 5;358(23):2433-46. [Free Abstract] [Full Text]

Accompanying Editorial
Ingelfinger JR.
Aliskiren and dual therapy in type 2 diabetes mellitus.
N Engl J Med. 2008 Jun 5;358(23):2503-5. [Free Extract] [Full Text]


The VA/NIH Acute Renal Failure Trial Network.
Intensity of Renal Support in Critically Ill Patients with Acute Kidney Injury.
N Engl J Med. 2008 May 20. Epub ahead of print [Free Full Text] [Discuss]

Accompanying Editorial
Bonventre JV.
Dialysis in Acute Kidney Injury -- More Is Not Better.
N Engl J Med. 2008 May 20. Epub ahead of print [Free Full Text]


Tolwani AJ et al.
Standard versus high-dose CVVHDF for ICU-related acute renal failure.
J Am Soc Nephrol. 2008 Jun;19(6):1233-8. [Free Abstract] [Full Text]

Accompanying Editorial
Mehta RL, Bouchard J.
Dialysis dosage in acute kidney injury: still a conundrum?
J Am Soc Nephrol. 2008 Jun;19(6):1046-8. [Full Text]

Original Research - Transplantation

Carroll RP et al.
The improvement in survival of expanded criteria donor kidneys with transplantation era.
Clin Transplant. 2008 May-Jun;22(3):324-32. [Free Abstract] [Full Text]

Hamdy AF et al.
Long-term efficacy and safety of a calcineurin inhibitor-free regimen in live-donor renal transplant recipients.
J Am Soc Nephrol. 2008 Jun;19(6):1225-32. [Free Abstract] [Full Text]

Shihab FS et al.
Conversion from cyclosporine to tacrolimus in patients at risk for chronic renal allograft failure: 60-month results of the CRAF Study.
Transplantation. 2008 May 15;85(9):1261-9. [Free Abstract] [Full Text]

Stevens RB et al.
Randomized Trial of Single-Dose Versus Divided-Dose Rabbit Anti-Thymocyte Globulin Induction in Renal Transplantation: An Interim Report.
Transplantation. 2008 May 27;85(10):1391-1399. [Free Abstract] [Full Text]

Opinion

Kunz R et al.
The COOPERATE trial: a letter of concern.
Lancet. 2008 May 10;371(9624):1575-6. [Full Text]

Olgaard K, Lewin E.
Use (or misuse) of vitamin D treatment in CKD and dialysis patients.
Nephrol Dial Transplant. 2008 Jun;23(6):1786-9; discuss 1789-3.
[Free Full Text]

Palmer S, Strippoli G.
Reply: Vitamin D compounds in chronic kidney disease: change may be needed for good!
Nephrol Dial Transplant. 2008 Jun;23(6):1789-1792. [Free Full Text]

Tonelli M et al.
Reply:
Nephrol. Dial. Transplant. 2008 23: 1792-1793. [Free Full Text]

Reviews

Fogazzi GB et al.
Urinalysis: core curriculum 2008.
Am J Kidney Dis. 2008 Jun;51(6):1052-67. [Free Full Text]

Hull RP, Goldsmith DJ.
Nephrotic syndrome in adults.
BMJ. 2008 May 24;336(7654):1185-9. [Free Abstract] [Full Text]

Ortiz A et al.
Recommendations and guidelines for the diagnosis and treatment of Fabry nephropathy in adults.
Nat Clin Pract Nephrol. 2008 Jun;4(6):327-36. [Free Abstract] [Full Text]

Cases

Sun L, Xu C.
Portal vein thrombosis as the first sign of nephrotic syndrome.
Nat Clin Pract Nephrol. 2008 Jun;4(6):342-5. [Free Full Text]

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We are pleased to provide free full text access to articles we select from the journals 'American Journal of Transplantation', 'Nephrology', 'Hemodialysis International' and 'Seminars in Dialysis'. Our thanks to the people at Blackwell Publishing for their support of Nephrology Now.

For many other of our selections, users will need individual or institutional subscriptions to access full text. Abstracts are freely available and where noted, some articles also have free full text access. Readers from developing nations can obtain full text access to some journals through the HINARI initiative and the Oxford Journals program.

Nephrology Now ISSN 1911-8880