Archive for December, 2009

December 14, 2009

Contraindicated Medication Use in Dialysis Patients Undergoing Percutaneous Coronary Intervention

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This observational study identified that patients with renal failure undergoing PCI (percutaneous coronary intervention) frequently receive contraindicated anticoagulants such as enoxaparin and eptifibatide.  Such exposure was associated with an increased risk of in-hospital major bleeding.

Comments Off on Contraindicated Medication Use in Dialysis Patients Undergoing Percutaneous Coronary Intervention Posted in Internal Medicine for Nephrologists, Vascular Disease/Calcification
December 14, 2009

Home Hemodialysis, Daily Hemodialysis, and Nocturnal Hemodialysis: Core Curriculum 2009

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This next addition to the AJKD Core Curriculum series provides a detailed overview of the topic of “Home Hemodialysis, Daily Hemodialysis and Nocturnal Hemodialysis”.

Comments Off on Home Hemodialysis, Daily Hemodialysis, and Nocturnal Hemodialysis: Core Curriculum 2009 Posted in AJKD Core Curriculum, Educational Resource, Hemodialysis
December 14, 2009

Everolimus with Very Low-Exposure Cyclosporine A in De Novo Kidney Transplantation: A Multicenter, Randomized, Controlled Trial

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Like sirolimus, everolimus is an inhibitor of mTOR. Previous studies have shown that the combination of a calcineurin inhibitor at full-dose with an mTOR inhibitor is associated with increased nephrotoxicity. This RCT compared standard-dose everolimus and low-dose cyclosporine to high-dose everolimus and very-low dose cyclosporine (measured by C2 levels, which are more accurate). There was no difference in renal function […]

Comments Off on Everolimus with Very Low-Exposure Cyclosporine A in De Novo Kidney Transplantation: A Multicenter, Randomized, Controlled Trial Posted in Renal Transplantation
December 14, 2009

Recurrent Idiopathic Membranous Nephropathy: Early Diagnosis by Protocol Biopsies and Treatment with Anti-Cd20 Monoclonal Antibodies

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In this cohort study, protocol biopsies were performed on a group of renal transplant patients with membranous nephropathy as their original renal disease. Approximately 40% of patients developed histologic recurrence by 4 years post-transplant. Several patients were treated with rituximab, which resulted in improvements in proteinuria.

Comments Off on Recurrent Idiopathic Membranous Nephropathy: Early Diagnosis by Protocol Biopsies and Treatment with Anti-Cd20 Monoclonal Antibodies Posted in Renal Transplantation
December 14, 2009

Interleukin-2 Receptor Antibody Reduces Rejection Rates and Graft Loss in Live-Donor Kidney Transplant Recipients

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This registry analysis found that compared to no antibody therapy, living-donor recipients who received IL-2 receptor antibody treatment at the time of transplant were at lower risk for acute rejection. At 5 years, IL-2 receptor antibody was also associated with a lower risk of overall graft failure at 5 years, and better renal function at 1 year, although […]

Comments Off on Interleukin-2 Receptor Antibody Reduces Rejection Rates and Graft Loss in Live-Donor Kidney Transplant Recipients Posted in Renal Transplantation
December 14, 2009

Proteinuria in Kidney Transplant Recipients: Prevalence, Prognosis, and Evidence-Based Management

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Proteinuria is a well-recognized risk factor for cardiovascular and progressive renal disease in the non-transplant population. This article reviews the literature on proteinuria in the renal transplant population.

Comments Off on Proteinuria in Kidney Transplant Recipients: Prevalence, Prognosis, and Evidence-Based Management Posted in Renal Transplantation