Archive for November, 2010

November 21, 2010

ASN 2010 Late Breaking Clinical Trial Results | SHARP, Preclot, more

The late breaking clinical trials session from the 2010 American Society of Nephrology meeting was held on November 20, 2010.  The following are summaries of the clinical trial results.  Where available, links to additional online resources are included.  Access to the full details of these studies awaits publication in peer reviewed journals. The Sharp Collaborative […]

1 Comment Posted in Clinical Trial Results, Experimental Nephrology
November 20, 2010

In-Center Hemodialysis Six Times per Week versus Three Times per Week

In this randomized controlled trial comparing conventional thrice weekly dialysis to frequent “daily” dialysis,  more frequent dialysis resulted in improvement in the composite outcomes of death or change in left ventricular mass and death or change in a physical-health composite score but prompted more frequent interventions related to vascular access This paper was presented at […]

Comments Off on In-Center Hemodialysis Six Times per Week versus Three Times per Week Posted in Hemodialysis
November 20, 2010

“Daily” Dialysis — Lessons from a Randomized, Controlled Trial

This editorial provides critical analysis of the paper “In-Center Hemodialysis Six Times per Week versus Three Times per Week”. Free full text provided by the New England Journal of Medicine.

Comments Off on “Daily” Dialysis — Lessons from a Randomized, Controlled Trial Posted in Editorial, Hemodialysis
November 8, 2010

Mycophenolate Mofetil vs Azathioprine for Remission Maintenance in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A Randomized Controlled Trial

In this publication by the EUVAS group, mycophenolate mofetil was found to be less effective than azathioprine for maintaining disease remission in ANCA-associated vasculitis. Free full text provided by JAMA.

Comments Off on Mycophenolate Mofetil vs Azathioprine for Remission Maintenance in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A Randomized Controlled Trial Posted in Vasculitis
November 8, 2010

Therapeutic Interventions for Systemic Vasculitis

This editorial provides critical analysis and commentary on the article ‘Mycophenolate Mofetil vs Azathioprine for Remission Maintenance in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A Randomized Controlled Trial’. Free full text provided by JAMA.

Comments Off on Therapeutic Interventions for Systemic Vasculitis Posted in Editorial, Vasculitis
November 8, 2010

Rejection of the Kidney Allograft

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This article summarizes the current understanding of mechanisms of rejection, including both cellular and antibody-mediated rejection.

Comments Off on Rejection of the Kidney Allograft Posted in Renal Transplantation, Review
November 8, 2010

Long-Term Experience With Kidney Transplantation From Hepatitis C-Positive Donors Into Hepatitis C-Positive Recipients

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Donors with hepatitis C virus (HCV) have often not been used for kidney transplants because of concerns of infecting the recipient with hepatitis C. This paper reports long-term outcomes of transplanting HCV+ kidneys into HCV+ recipients. There was no difference in patient or graft survival among recipients of HCV+ or HCV- kidneys, and very few […]

Comments Off on Long-Term Experience With Kidney Transplantation From Hepatitis C-Positive Donors Into Hepatitis C-Positive Recipients Posted in Renal Transplantation
November 8, 2010

Analysis of factors that affect outcome after transplantation of kidneys donated after cardiac death in the UK: a cohort study

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Donation after donors undergo cardiac death is a growing source of kidney transplant. These kidneys have a higher fate of delayed graft function. This UK registry study found 5-year graft function and survival of kidneys from donors after cardiac death were similar to that from brain-dead donors.

Comments Off on Analysis of factors that affect outcome after transplantation of kidneys donated after cardiac death in the UK: a cohort study Posted in Renal Transplantation
November 8, 2010

Policy Statement of Canadian Society of Transplantation and Canadian Society of Nephrology on Organ Trafficking and Transplant Tourism

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The Istanbul Declaration was an international statement condemning the practices of organ trafficking and transplant tourism. This paper outlines an approach for physicians to counsel patients about the risks of commercial renal transplantation beforehand, physicians’ duties towards a patient who wishes to proceed with a commercial transplant, and their responsibilities once a patient returns seeking […]

Comments Off on Policy Statement of Canadian Society of Transplantation and Canadian Society of Nephrology on Organ Trafficking and Transplant Tourism Posted in Renal Transplantation
November 1, 2010

Similar Outcomes With Hemodialysis and Peritoneal Dialysis in Patients With End-Stage Renal Disease

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In one of the largest retrospective observational studies comparing dialysis modality and survival, the authors compared the survival of 620 020 incident Hemodialysis patients and 64 046 incident Peritoneal Dialysis patients treated in The United States between 1996-2004. The authors demonstrated improving survival for PD patients with similar survival compared to HD patients in  a […]

Comments Off on Similar Outcomes With Hemodialysis and Peritoneal Dialysis in Patients With End-Stage Renal Disease Posted in Hemodialysis, Peritoneal Dialysis
November 1, 2010

ACLASTA (zoledronic acid 5mg/100mL) solution for intravenous infusion – Association with renal dysfunction

Novartis in collaboration with Health Canada, is notifying healthcare professionals and the public of reports of renal impairment and renal failure requiring dialysis or with fatal outcome that occurred in patients with history of renal impairment or other risk factors receiving ACLASTA (zoledronic acid).

Comments Off on ACLASTA (zoledronic acid 5mg/100mL) solution for intravenous infusion – Association with renal dysfunction Posted in Acute Kidney Injury
November 1, 2010

Pharmacist-Physician Comanagement of Hypertension and Reduction in 24-Hour Ambulatory Blood Pressures

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This prospective, cluster-randomized, controlled clinical trial examined the impact of pharmacist-primary care physician collaborative management of hypertension.  Patients receiving the intervention achieved greater reduction in 24-hour BP and a high rate of BP control.

1 Comment Posted in Hypertension
November 1, 2010

Antiplatelet agents for the prevention of arteriovenous fistula and graft thrombosis: a meta analysis.

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This meta-analysis suggests that antiplatelet agents reduce the rate of thrombosis in arteriovenous fistulas but not arteriovenous grafts.

Comments Off on Antiplatelet agents for the prevention of arteriovenous fistula and graft thrombosis: a meta analysis. Posted in Vascular Access