Archive for August, 2011

August 5, 2011

Selection Bias Explains Apparent Differential Mortality between Dialysis Modalities

.   .   

This study shows that the previously explained difference in relative risk of death with peritoneal dialysis patients compared with those treated with hemodialysis is likely related to selection bias. No difference was found in the relative risk of mortality for peritoneal dialysis compared with hemodialysis among individuals who received ≥4 months of predialysis care and […]

Comments Off on Selection Bias Explains Apparent Differential Mortality between Dialysis Modalities Posted in Hemodialysis, Peritoneal Dialysis
August 5, 2011

Moderate dietary sodium restriction added to angiotensin converting enzyme inhibition compared with dual blockade in lowering proteinuria and blood pressure: randomised controlled trial

.   .   

This small randomized trial including patients with non-diabetic nephropathy looked at the addition of dietary sodium restriction or angiotensin receptor blockade (or their combination), in patients receiving background treatment with angiotensin converting enzyme (ACE) inhibition at maximum dose. Dietary sodium restriction to a level recommended in guidelines was more effective than dual blockade for reduction […]

Comments Off on Moderate dietary sodium restriction added to angiotensin converting enzyme inhibition compared with dual blockade in lowering proteinuria and blood pressure: randomised controlled trial Posted in Chronic Kidney Disease, Hypertension
August 5, 2011

Monitoring and Managing Graft Health in the Kidney Transplant Recipient

.   .   

This is an introduction to a collection of articles focusing on care of the healthy renal transplant recipient after the early post-transplant. The articles in this section focus on the components of a routine clinic visit, the metabolic syndrome, proteinuria and anemia. The focus is on recognizing and managing those factors that play an important […]

1 Comment Posted in Renal Transplantation
August 5, 2011

Desensitization in HLA-Incompatible Kidney Recipients and Survival

.   .   

For patients with high levels of anti-HLA antibodies, waiting times for a kidney transplant are significantly longer than average. Desensitization allows the barrier of a positive crossmatch to be overcome, but there are concerns related to the long-term risks of chronic antibody-mediated rejection. This paper reports an experienced centre’s results with a group of patients […]

Comments Off on Desensitization in HLA-Incompatible Kidney Recipients and Survival Posted in Renal Transplantation
August 5, 2011

Improved Rejection Prophylaxis With an Initially Intensified Dosing Regimen of Enteric-Coated Mycophenolate Sodium in De Novo Renal Transplant Recipients

.   .   

Previous studies have defined a therapeutic area under the curve for mycophenolic acid (MPA) in the early post-transplant period, although the majority of centers do not perform routine MPA monitoring. This paper presents results of a randomized controlled trial comparing an initial higher dose of MPA to standard dosing in patients treated with steroids, cyclosporine […]

Comments Off on Improved Rejection Prophylaxis With an Initially Intensified Dosing Regimen of Enteric-Coated Mycophenolate Sodium in De Novo Renal Transplant Recipients Posted in Renal Transplantation
August 5, 2011

The ORION Study: Comparison of Two Sirolimus-Based Regimens versus Tacrolimus and Mycophenolate Mofetil in Renal Allograft Recipients

.   .   

This randomized controlled trial in de novo renal transplant recipients compared a standard immunosuppressive protocol of daclizumab induction, tacrolimus, mycophenolate mofetil (MMF) and steroids, to either: sirolimus and tacrolimus, with tacrolimus discontinued by four months post-transplant, or sirolimus and MMF. The sirolimus and MMF group was stopped early due to a high incidence of acute […]

Comments Off on The ORION Study: Comparison of Two Sirolimus-Based Regimens versus Tacrolimus and Mycophenolate Mofetil in Renal Allograft Recipients Posted in Renal Transplantation