Archive for October, 2011

October 8, 2011

Long Interdialytic Interval and Mortality among Patients Receiving Hemodialysis

This administrative study using USRDS data demonstrated an increased risk of all-cause mortality and admissions to hospital due to cardiovascular events during the long (2 day) interdialytic interval.  This study alludes to the benefit of more frequent hemodialysis and suggests that current dialysis scheduling may need to be revisited.  

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October 8, 2011

Acetylcysteine for Prevention of Renal Outcomes in Patients Undergoing Coronary and Peripheral Vascular Angiography: Main Results From the Randomized Acetylcysteine for Contrast-Induced Nephropathy Trial (ACT)

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This randomized trial of over 2300 patients undergoing coronary and peripheral vascular angiography failed to show that acetylcysteine reduces the risk of contrast-induced acute kidney injury, need for dialysis or mortality.  This study contributes to the growing body of literature suggesting the lack of benefit of using NAC in the prevention of contrast-induced nephropathy.

Comments Off on Acetylcysteine for Prevention of Renal Outcomes in Patients Undergoing Coronary and Peripheral Vascular Angiography: Main Results From the Randomized Acetylcysteine for Contrast-Induced Nephropathy Trial (ACT) Posted in Acute Kidney Injury
October 8, 2011

2011 Prevention in Renal Disease Conference

Watch all sessions from the 2011 Prevention in Renal Disease Conference. http://ukidney.com/prevention-in-renal-disease-conference-toronto-11-dp1

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October 8, 2011

iPhone App ‘Calculate by QxMD’ adds PD Content

The app ‘Calculate by QxMD’ now includes: Access Care and Complications Guide PD Prescription Calculator & Guide ISPD & CSN Guidelines MATCH D – Home Dialysis Patient Selection tool General Nephrology Calculators Learn more http://www.qxmd.com/peritoneal-dialysis-management-tools-added-to-calculate-by-qxmd Download now http://itunes.apple.com/app/calculate-medical-calculator/id361811483?mt=8

Comments Off on iPhone App ‘Calculate by QxMD’ adds PD Content Posted in Educational Resource, Peritoneal Dialysis
October 8, 2011

New DaVita Peritoneal Dialysis Webinar Series

A new series of DaVita’s peritoneal dialysis (PD) webinars began in October and will continue on the first Friday of each month. The clinically focused webinars will be presented by physician experts in home dialysis. The next webinar, The Pros and Cons of CAPD vs. CCPD, is hosted by Dr Tom Tucker and will take […]

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October 8, 2011

Podocyte disorders: core curriculum 2011

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This paper provides point form review of normal and pathological glomerular function, as well as major types of podocyte disorders including minimal change disease, membranous nephropathy and FSGS.

Comments Off on Podocyte disorders: core curriculum 2011 Posted in AJKD Core Curriculum, Glomerulonephritis
October 8, 2011

Clinical practice. Chronic hypertension in pregnancy.

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This is an excellent review on the management of pre-existing hypertension in the setting of pregnancy.

Comments Off on Clinical practice. Chronic hypertension in pregnancy. Posted in Hypertension, Pregnancy and Hypertension/Renal Disease
October 8, 2011

Persistent Asymptomatic Isolated Microscopic Hematuria in Israeli Adolescents and Young Adults and Risk for End-Stage Renal Disease

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This study linked an ESRD registry to retrospective medical data for persons aged 16-25 examined for military fitness.  It showed that persistent asymptomatic microscopic hematuria was associated with an increased risk of ESRD, with an adjusted hazard ratio of 18.5 [95% CI, 12.4-27.6].  While the absolute risk of ESRD in patients with microscopic hematuria remains […]

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October 8, 2011

Predialysis nephrology care of older patients approaching end-stage renal disease.

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This retrospective study failed to demonstrate significant improvements in 1-year survival rates after dialysis initiation despite a trend to earlier nephrology consultation in older adults with chronic kidney disease.  The accompanying editorials ask questions about the role and benefit of predialysis care. Editorials Earlier Nephrology Consultation Is Not Associated With Improved Survival: Comment on “Predialysis […]

Comments Off on Predialysis nephrology care of older patients approaching end-stage renal disease. Posted in Chronic Kidney Disease
October 8, 2011

The Impact of Conversion From Prograf to Generic Tacrolimus in Liver and Kidney Transplant Recipients With Stable Graft Function

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Most immunosuppressive agents used in transplantation will become available as generics in the next few years. This might significantly reduce the costs of transplantation, but there is concern that the pharmacokinetics of generic formulations will not be the same as the brand-name drug, resulting in either inadequate immunosuppression or excessive toxicity. In this paper, stable […]

1 Comment Posted in Renal Transplantation
October 8, 2011

Randomized trial of immunosuppressive regimens in renal transplantation

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Most randomized controlled trials of immunosuppressive regimens have follow-up of only one to three years, which may not be relevant in an era where average graft survival is a decade or more. This paper reports long-term results of a randomized controlled trial comparing tacrolimus/sirolimus, tacrolimus/mycophenolate mofetil and cyclosporine/sirolimus. All patients received induction with an interlukin-2 […]

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October 8, 2011

Autoantibodies Specific for the Phospholipase A2 Receptor in Recurrent and De Novo Membranous Nephropathy

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An important recent story in glomerulonephritis has been the discovery of the anti-phospholipase A2 receptor antibodies (PLA2R Ab) in many patients with membranous nephropathy. This paper aims to relate the presence or absence of this antibody to the likelihood of recurrence. Patients with de novo membranous nephropathy did not produce PLA2R Ab. Surprisingly, the antibody […]

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October 8, 2011

Graft Loss Due to Recurrent Lupus Nephritis in Living-Related Kidney Donation

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Recurrence of lupus nephritis is not uncommon, and treatment can be difficult. This retrospective cohort study using the UNOS registry examined the risk of graft loss among living-donor recipients of a kidney transplant. Surprisingly, patients who received a zero-mismatched kidney had the lowest incidence of graft loss due to recurrent lupus nephritis. Free full text […]

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