Archive for November, 2012

November 25, 2012

Association Between a Chloride-Liberal vs Chloride-Restrictive Intravenous Fluid Administration Strategy and Kidney Injury in Critically Ill Adults

.   .   

This prospective, open label trial studied 760 consecutive ICU patients that preferentially received chloride-poor (eg lactate solution, balanced solution or 20% albumin) intravenous solutions. The primary outcomes showed that the use of chloride-restricted solutions was associated with a decreased incidence of AKI and use of RRT. There was no difference mortality, length of stay or […]

Comments Off on Association Between a Chloride-Liberal vs Chloride-Restrictive Intravenous Fluid Administration Strategy and Kidney Injury in Critically Ill Adults Posted in Acute Kidney Injury, Fluid & Electrolytes
November 25, 2012

iPad app ‘Read’ finds best Nephrology research and connects to full text PDFs with one tap.

‘Read by QxMD’ provides a single place to keep up with new medical research, read outstanding topic reviews and search PubMed. The iPad form factor provides a simple interface that drives discovery and seamless access to the medical literature by reformatting it into a personalized digital medical journal. Download now ==> http://qx.md/read Features: ✔ Keep […]

Comments Off on iPad app ‘Read’ finds best Nephrology research and connects to full text PDFs with one tap. Posted in Educational Resource
November 25, 2012

Survey on Nephrology care after acute kidney injury

This survey examines the clinical factors that influence patient follow-up (creatinine testing or follow-up appointment with a nephrologist) in the community after a hospitalization with acute kidney injury. Online survey: http://fluidsurveys.com/s/Followup-AKI/

Comments Off on Survey on Nephrology care after acute kidney injury Posted in Study Invitation
November 25, 2012

Mortality of Dialysis Patients According to Influenza and Pneumococcal Vaccination Status

.   .   

This retrospective observational study showed that vaccination against influenza and pneumococcal disease is associated with improved survival in dialysis patients.

Comments Off on Mortality of Dialysis Patients According to Influenza and Pneumococcal Vaccination Status Posted in Hemodialysis, Internal Medicine for Nephrologists, Peritoneal Dialysis
November 25, 2012

Ultrafiltration in Decompensated Heart Failure with Cardiorenal Syndrome

.   .   

This randomized controlled trial compared ultrafiltration versus stepped pharmacologic therapy in patients with acute decompensated heart failure and a decline in kidney function (cardiorenal syndrome). Ultrafiltration was found to be inferior in achieving the bivariate endpoint in change in serum creatinine and body weight after 96 hours. The ultrafiltration group experienced a higher rate of […]

Comments Off on Ultrafiltration in Decompensated Heart Failure with Cardiorenal Syndrome Posted in Acute Kidney Injury, Cardiorenal Syndrome, Critical Care
November 25, 2012

KDIGO Clinical Practice Guideline for the Management of Blood Pressure in Chronic Kidney Disease

This KDIGO clinical practice guideline provides guidance on blood pressure management for all non-dialysis-dependent CKD patients and kidney transplant recipients.

Comments Off on KDIGO Clinical Practice Guideline for the Management of Blood Pressure in Chronic Kidney Disease Posted in Chronic Kidney Disease, Hypertension
November 25, 2012

General Medical Care of the Dialysis Patient: Core Curriculum 2013.

.   .   

This review from the AJKD Core Curriculum series provides a nice summary of medical issues to address while managing dialysis patients.

Comments Off on General Medical Care of the Dialysis Patient: Core Curriculum 2013. Posted in AJKD Core Curriculum, Hemodialysis
November 25, 2012

Hydroxyethyl Starch or Saline for Fluid Resuscitation in Intensive Care.

.   .   

This randomized controlled trial compared the use of hydroxyethyl starch (HES) versus saline for fluid resuscitation. While there was no significant difference in 90-day mortality, patients who received resuscitation with HES were more likely to have renal injuryand be treated with renal-replacement therapy.

Comments Off on Hydroxyethyl Starch or Saline for Fluid Resuscitation in Intensive Care. Posted in Acute Kidney Injury, Clinical Trial Results
November 25, 2012

Hemodialysis and peritoneal dialysis are associated with similar outcomes for end-stage renal disease treatment in Canada

.   .   

This study using Canadian Organ Replacement Registry (CORR) data compared PD survival relative to HD. Overall survival for the study period favored PD in the first 18 months and HD after 36 months. Looking at the 2001-04 cohort, survival favored PD for the first 2 years only and then was similar for both HD and […]

Comments Off on Hemodialysis and peritoneal dialysis are associated with similar outcomes for end-stage renal disease treatment in Canada Posted in Chronic Kidney Disease, Hemodialysis, Peritoneal Dialysis
November 4, 2012

Effect of Cinacalcet on Cardiovascular Disease in Patients Undergoing Dialysis

In this randomized, placebo controlled trial, patients on hemodialysis with moderate-to-severe secondary hyperparathyroidism were randomized to receive either cinacalcet or placebo.   No difference was seen in the primary composite end point (time until death, myocardial infarction, hospitalization for unstable angina, heart failure, or a peripheral vascular event) between cinacalcet (48.2%) versus placebo (49.2%) HR 0.93; 95% CI, 0.85 to […]

Comments Off on Effect of Cinacalcet on Cardiovascular Disease in Patients Undergoing Dialysis Posted in Bone Mineral Metabolism, Vascular Disease/Calcification
November 4, 2012

Cardiorenal End Points in a Trial of Aliskiren for Type 2 Diabetes

As we originally reported towards the end of 2011, the ALTITUDE trial was terminated early.  The data from this trial was reported on November 3, 2012 at the American Society of Nephrology Kidney Week by Dr. Parving and simultaneously published online by the New England Journal of Medicine. In ALTITUDE, a double-blind, randomized controlled trial, patients […]

Comments Off on Cardiorenal End Points in a Trial of Aliskiren for Type 2 Diabetes Posted in Diabetes, RAS Blockade
November 4, 2012

Tolvaptan in Patients with Autosomal Dominant Polycystic Kidney Disease

This long awaited clinical trial was presented on November 3, 2012 at the American Society of Nephrology Kidney Week. This multicenter, double-blind, placebo-controlled trial enrolled patients with autosomal dominant polycystic kidney disease who were age 18 to 50 years, had total kidney volume of ≥ 750 ml and  an estimated CrCl of  ≥ 60 ml per min. […]

Comments Off on Tolvaptan in Patients with Autosomal Dominant Polycystic Kidney Disease Posted in Polycystic Kidney Disease