Archive for August, 2013

August 23, 2013

Glomerular diseases seen with cancer and chemotherapy: a narrative review

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This review describes the association of glomerular diseases in the context of solid tumors, hematological malignancies, stem cell transplantation, and chemotherapeutic agents. It also discusses the intricacies of diagnosing and managing these disorders.

1 Comment Posted in Clinical Nephrology, General Nephrology, Review
August 23, 2013

Long-term follow-up of patients with severe ANCA-associated vasculitis comparing plasma exchange to intravenous methylprednisolone treatment is unclear

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This longer term follow-up of PLEX for the treatment of ANCA-associated vasculitis in patients with severely impaired renal function are disappointing. The data suggest that PLEX does not significantly benefit these patients. Current trials are ongoing as to the role of PLEX in ANCA-associated vasculitis.

Comments Off on Long-term follow-up of patients with severe ANCA-associated vasculitis comparing plasma exchange to intravenous methylprednisolone treatment is unclear Posted in Clinical Trial Results, Glomerulonephritis
August 23, 2013

Role of Vaptans in the Management of Hyponatremia

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In order to use vasopressin receptor antagonists safely, one requires a comprehensive understanding of their indications and contraindications. This review provides an in-depth look at vaptans and their role in the management of euvolemic and hypervolemic hyponatremia.

Comments Off on Role of Vaptans in the Management of Hyponatremia Posted in Clinical Nephrology, Fluid & Electrolytes, Review
August 23, 2013

Relationship Between the Prognostic Expectations of Seriously Ill Patients Undergoing Hemodialysis and Their Nephrologists

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This very interesting study emphasizes the need for better communication strategies between patients and their health care providers. Although in this cohort, patients’ expectations about 1-year survival were more accurate than those of their nephrologists; their longer-term survival expectations were significantly overestimated. In order to optimally guide their choices, patients need to have better prognostic […]

Comments Off on Relationship Between the Prognostic Expectations of Seriously Ill Patients Undergoing Hemodialysis and Their Nephrologists Posted in Clinical Nephrology, Educational Resource, Hemodialysis
August 23, 2013

Risk of acute kidney injury associated with the use of fluoroquinolones

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This interesting study examined the risk of acute kidney injury when using fluoroquinolones. The current use of this class of antibiotics in patients had a >2-fold (95% confidence interval [CI] 1.74-2.73) higher adjusted relative risk (RR) of acute kidney injury compared with no use. Furthermore, the dual use of fluoroquinolones and renin-angiotensin-system blockers had RR […]

2 Comments Posted in Acute Kidney Injury, General Nephrology
August 23, 2013

Androgen Deprivation Therapy and Risk of Acute Kidney Injury in Patients With Prostate Cancer

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This nested case-control analysis showed that in patients with nonmetastatic prostate cancer, there was a significant increase in the incidence of acute kidney injury with androgen deprivation therapy. These findings need to be further investigated and studied.

1 Comment Posted in Acute Kidney Injury, General Nephrology
August 23, 2013

Efficacy of Remission-Induction Regimens for ANCA-Associated Vasculitis

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This randomized double-blind noninferiority trial compared the 18-month efficacy of rituximab + placebo vs cyclophosphamide + azathioprine for the treatment of ANCA-associated vasculitis. Of the 197 patients enrolled, 64% of the patients in the rituximab group, as compared with 53% of the patients in the cyclophosphamide-azathioprine group, had a complete remission by 6 months. The […]

1 Comment Posted in Clinical Nephrology, General Nephrology, Glomerulonephritis
August 1, 2013

Peritoneal Dialysis Access Guide

This guide to peritoneal dialysis access is based in part on ISPD guidelines. It provides a concise review of catheter insertion and post-procedure care, non-infectious complications of PD catheters, infectious complications of PD catheters and antibiotic dosing guidelines.

Comments Off on Peritoneal Dialysis Access Guide Posted in Educational Resource, Peritoneal Dialysis