Archive for November, 2014

November 16, 2014

Follow-up of Blood-Pressure Lowering and Glucose Control in Type 2 Diabetes

.   .   

In this 6-year follow-up study of patients enrolled in ADVANCE, there was no evidence that intensive glucose control during the trial led to long-term benefits with respect to mortality or macrovascular events. Though event rates were small, there was a reduction in end-stage renal disease in those patients in the intensive glucose arm, hazard ratio 0.54; […]

Comments Off on Follow-up of Blood-Pressure Lowering and Glucose Control in Type 2 Diabetes Posted in Chronic Kidney Disease, Diabetes
November 16, 2014

Rituximab versus azathioprine for maintenance in ANCA-associated vasculitis

.   .   

In this RCT, patients with ANCA-associated vasculitis who achieved complete remission after a cyclophosphamide-glucocorticoid regimen were randomly assigned to receive intermittent rituximab (days 0 and 14 and at months 6, 12, and 18) or daily azathioprine until month 22.  Major relapse was less common in the rituximab arm than the azathioprine arm (5% vs 29%) […]

Comments Off on Rituximab versus azathioprine for maintenance in ANCA-associated vasculitis Posted in Vasculitis
November 16, 2014

Integration of Acid–Base and Electrolyte Disorders

.   .   

This review, appropriate for trainees and practicing physicians, provides an approach to the diagnosis of acid-base disorders.

Comments Off on Integration of Acid–Base and Electrolyte Disorders Posted in Fluid & Electrolytes
November 16, 2014

Gestational Hypertension and Preeclampsia in Living Kidney Donors

.   .   

This retrospective cohort study showed an increased risk of gestational hypertension or preeclampsia in women who have been living kidney donors, 11% in donors vs 5% in non-donors (OR 2.4; 95% CI, 1.2 to 5.0; P=0.01).

Comments Off on Gestational Hypertension and Preeclampsia in Living Kidney Donors Posted in Pregnancy and Hypertension/Renal Disease, Renal Transplantation
November 16, 2014

Blood Pressure in Early Autosomal Dominant Polycystic Kidney Disease

In patients with early PKD, dual blockage of the RAS system provided no advantage over ACE inhibitor alone.  Patients targeted to the standard blood pressure target (120/70 to 130/80 mm Hg) vs a low blood-pressure target (95/60 to 110/75 mm Hg) had reduced annual % increase in total kidney volume (6.6% vs. 5.6%, P=0.006) and more reduction in […]

Comments Off on Blood Pressure in Early Autosomal Dominant Polycystic Kidney Disease Posted in Chronic Kidney Disease, Polycystic Kidney Disease
November 16, 2014

Successful Delivery of RRT in Ebola Virus Disease

.   .   

This timely article describes the protocol used at Emory University Hospital to provide dialysis in a patient with Ebola virus and proposes clinical practice guidelines for acute dialysis in this infection.

Comments Off on Successful Delivery of RRT in Ebola Virus Disease Posted in Acute Kidney Injury, Clinical Nephrology, Critical Care
November 16, 2014

Perioperative Aspirin and Clonidine and Risk of Acute Kidney Injury

.   .   

In this sub-study of the POISE-2 study, neither ASA or clonidine reduced the risk of acute kidney injury after non-cardiac surgery. Of note, aspirin increased the risk of major bleeding (which was associated with a greater risk of acute kidney injury).  As well, clonidine increased the risk of clinically important hypotension (which was associated with […]

Comments Off on Perioperative Aspirin and Clonidine and Risk of Acute Kidney Injury Posted in Acute Kidney Injury
November 16, 2014

Association of Sickle Cell Trait With Chronic Kidney Disease and Albuminuria in African Americans

.   .   

This observational study identified that among African Americans, sickle cell trait was associated with an increased risk of chronic kidney disease and albuminuria, compared with noncarriers.

Comments Off on Association of Sickle Cell Trait With Chronic Kidney Disease and Albuminuria in African Americans Posted in Chronic Kidney Disease