December 22, 2011

Antibody Removal Before ABO-Incompatible Renal Transplantation: How Much Plasma Exchange Is Therapeutic?

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Desensitization protocols to allow for transplantation across the ABO-blood barrier have become accepted in renal transplantation over the last decade. Plasma exchange is a frequent part of these protocols, and physically removes the antibodies from the circulation. This single-centre cohort study looked at the number of plasma exchange sessions required to reach a threshold where it was felt that transplantation could safely proceed. It also found a starting antibody level above which desensitization was unlikely to be successful.

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