November 25, 2012

Association Between a Chloride-Liberal vs Chloride-Restrictive Intravenous Fluid Administration Strategy and Kidney Injury in Critically Ill Adults

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This prospective, open label trial studied 760 consecutive ICU patients that preferentially received chloride-poor (eg lactate solution, balanced solution or 20% albumin) intravenous solutions. The primary outcomes showed that the use of chloride-restricted solutions was associated with a decreased incidence of AKI and use of RRT. There was no difference mortality, length of stay or need for RRT after discharge.

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