November 16, 2014

Blood Pressure in Early Autosomal Dominant Polycystic Kidney Disease

In patients with early PKD, dual blockage of the RAS system provided no advantage over ACE inhibitor alone.  Patients targeted to the standard blood pressure target (120/70 to 130/80 mm Hg) vs a low blood-pressure target (95/60 to 110/75 mm Hg) had reduced annual % increase in total kidney volume (6.6% vs. 5.6%, P=0.006) and more reduction in urinary albumin excretion (3.77% vs 2.43% , P<0.001).  However, there was no difference in rate of change in estimated GFR.

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Chronic Kidney Disease, Polycystic Kidney Disease