Archive for the ‘Acute Kidney Injury’ Category

November 16, 2014

Successful Delivery of RRT in Ebola Virus Disease

.   .   

This timely article describes the protocol used at Emory University Hospital to provide dialysis in a patient with Ebola virus and proposes clinical practice guidelines for acute dialysis in this infection.

Comments Off on Successful Delivery of RRT in Ebola Virus Disease Posted in Acute Kidney Injury, Clinical Nephrology, Critical Care
November 16, 2014

Perioperative Aspirin and Clonidine and Risk of Acute Kidney Injury

.   .   

In this sub-study of the POISE-2 study, neither ASA or clonidine reduced the risk of acute kidney injury after non-cardiac surgery. Of note, aspirin increased the risk of major bleeding (which was associated with a greater risk of acute kidney injury).  As well, clonidine increased the risk of clinically important hypotension (which was associated with […]

Comments Off on Perioperative Aspirin and Clonidine and Risk of Acute Kidney Injury Posted in Acute Kidney Injury
April 19, 2014

Non-selective β Blockers Increase Risk for Hepatorenal Syndrome and Death in Patients with Cirrhosis and Spontaneous Bacterial Peritonitis

.   .   

This interesting study of non-selective beta blockers in patients with cirrhosis and spontaneous bacterial peritonitis shows that their use increases the risk of acute kidney injury and hepatorenal syndrome in this population. The authors advise against their use in these patients. Furthermore, they worsen hemodynamic instability as well as increase length of hospitalization.

3 Comments Posted in Acute Kidney Injury
April 19, 2014

High versus Low Blood-Pressure Target in Patients with Septic Shock

.   .   

This multicentre, open label trial randomized over 700 patients with septic shock to undergo resuscitation to MAP target of 80-85 mmHg or 65-70 mmHg. The primary outcome of mortality was no different in either group at 28 or 90 days. However, the higher target group required less renal replacement therapy.

Comments Off on High versus Low Blood-Pressure Target in Patients with Septic Shock Posted in Acute Kidney Injury, Clinical Nephrology, Clinical Trial Results, General Nephrology
December 21, 2013

Treatment of severe alcoholic hepatitis with corticosteroids and pentoxifylline.

.   .   

This RCT in alcoholic hepatitis showed a trend to a reduction in hepatorenal syndrome in patients treated with pentoxifylline-prednisolone compared to placebo-prednisolone group (8.4% vs 15.3%, P = .07).

Comments Off on Treatment of severe alcoholic hepatitis with corticosteroids and pentoxifylline. Posted in Acute Kidney Injury
August 23, 2013

Risk of acute kidney injury associated with the use of fluoroquinolones

.   .   

This interesting study examined the risk of acute kidney injury when using fluoroquinolones. The current use of this class of antibiotics in patients had a >2-fold (95% confidence interval [CI] 1.74-2.73) higher adjusted relative risk (RR) of acute kidney injury compared with no use. Furthermore, the dual use of fluoroquinolones and renin-angiotensin-system blockers had RR […]

2 Comments Posted in Acute Kidney Injury, General Nephrology
August 23, 2013

Androgen Deprivation Therapy and Risk of Acute Kidney Injury in Patients With Prostate Cancer

.   .   

This nested case-control analysis showed that in patients with nonmetastatic prostate cancer, there was a significant increase in the incidence of acute kidney injury with androgen deprivation therapy. These findings need to be further investigated and studied.

1 Comment Posted in Acute Kidney Injury, General Nephrology
April 1, 2013

Biomarkers in Nephrology: Core Curriculum 2013

.   .   

This article of the AJKD Core Curriculum, reviews biomarkers of kidney disease in the settings of acute kidney injury, chronic kidney disease,nephrotoxin exposure and glomerulonephritis.

Comments Off on Biomarkers in Nephrology: Core Curriculum 2013 Posted in Acute Kidney Injury, AJKD Core Curriculum, Chronic Kidney Disease, Glomerulonephritis
April 1, 2013

Association of hydroxyethyl starch administration with mortality and acute kidney injury in critically ill patients requiring volume resuscitation: a systematic review and meta-analysis.

.   .   

Recently, 7 trials investigating the role of hydroxyethyl starch in the critically ill were retracted because of scientific misconduct. This meta-analysis, which excludes these studies, indicates an increased risk of death and acute kidney injury in critically ill patients requiring acute volume resuscitation.

Comments Off on Association of hydroxyethyl starch administration with mortality and acute kidney injury in critically ill patients requiring volume resuscitation: a systematic review and meta-analysis. Posted in Acute Kidney Injury, Critical Care
April 1, 2013

Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases

.   .   

This retrospective observational analysis of administrative databases reveals an association between high potency statins and hospital admission for acute kidney injury. This study does not clarify whether this relationship is causal.

Comments Off on Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases Posted in Acute Kidney Injury
January 28, 2013

Adverse Effects Associated With Transcatheter Aortic Valve Implantation: A Meta-analysis of Contemporary Studies.

.   .   

This meta-analysis identifies acute kidney injury requiring dialysis as a common complication of transcatheter aortic valve implantation, occurring in approximately 5% of patients.

Comments Off on Adverse Effects Associated With Transcatheter Aortic Valve Implantation: A Meta-analysis of Contemporary Studies. Posted in Acute Kidney Injury
November 25, 2012

Association Between a Chloride-Liberal vs Chloride-Restrictive Intravenous Fluid Administration Strategy and Kidney Injury in Critically Ill Adults

.   .   

This prospective, open label trial studied 760 consecutive ICU patients that preferentially received chloride-poor (eg lactate solution, balanced solution or 20% albumin) intravenous solutions. The primary outcomes showed that the use of chloride-restricted solutions was associated with a decreased incidence of AKI and use of RRT. There was no difference mortality, length of stay or […]

Comments Off on Association Between a Chloride-Liberal vs Chloride-Restrictive Intravenous Fluid Administration Strategy and Kidney Injury in Critically Ill Adults Posted in Acute Kidney Injury, Fluid & Electrolytes
November 25, 2012

Ultrafiltration in Decompensated Heart Failure with Cardiorenal Syndrome

.   .   

This randomized controlled trial compared ultrafiltration versus stepped pharmacologic therapy in patients with acute decompensated heart failure and a decline in kidney function (cardiorenal syndrome). Ultrafiltration was found to be inferior in achieving the bivariate endpoint in change in serum creatinine and body weight after 96 hours. The ultrafiltration group experienced a higher rate of […]

Comments Off on Ultrafiltration in Decompensated Heart Failure with Cardiorenal Syndrome Posted in Acute Kidney Injury, Cardiorenal Syndrome, Critical Care