Archive for the ‘Contrast Nephropathy’ Category

February 9, 2017

Comparative Effectiveness of 12 Treatment Strategies for Preventing Contrast-Induced Acute Kidney Injury: A Systematic Review and Bayesian Network Meta-analysis

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This systematic review included 150 trials with 31,631 participants and 4,182 contrast-induced AKI events assessing 12 different interventions. The conclusion was that high-dose statin plus NAC or high-dose statin alone were ranked the one/two for preventing contrast-induced AKI with no significant changes noted in metaregressions or subgroup and sensitivity analyses.  

No Comments Posted in Acute Kidney Injury, Contrast Nephropathy
September 21, 2015

Randomized Trial of Bicarbonate or Saline Study for the Prevention of Contrast-Induced Nephropathy in Patients with CKD

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Sodium bicarbonate vs sodium chloride has always plagued those of us trying to prevent acute contrast nephropathy.  This prospective, double-blind, multicenter randomized clinical trial of 391 with eGFR < 45 ml/min were randomized to either infusion.  There was no difference in the primary composite outcome of mortality, dialysis, or a sustained 20% reduction in eGFR at 6 months […]

No Comments Posted in Acute Kidney Injury, Clinical Nephrology, Contrast Nephropathy
October 18, 2009

Sodium Bicarbonate for the Prevention of Contrast Induced-Acute Kidney Injury: A Systematic Review and Meta-analysis

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This meta-analysis examined the use of sodium bicarbonate vs sodium chloride for the prevention of contrast induced nephropathy. The authors detected significant heterogeneity that was largely explained by trial size and publication status. Among the large randomized trials, there was no benefit for hydration with sodium bicarbonate. Studies suggesting a benefit of sodium bicarbonate was […]

2 Comments Posted in Acute Kidney Injury, Contrast Nephropathy
October 18, 2009

Sodium Bicarbonate Plus Isotonic Saline Versus Saline for Prevention of Contrast-Induced Nephropathy in Patients Undergoing Coronary Angiography: A Randomized Controlled Trial

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This randomized double-blind trial compares the combination of sodium bicarbonate and isotonic saline with that of isotonic saline alone in preventing contrast-induced nephropathy (CIN). Of the 256 patients randomized, nine patients (7.4%) receiving sodium bicarbonate developed CIN as opposed to 7 patients (5.9%) in the saline group, which was not statistically different. The authors conclude […]

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April 1, 2009

Renal protective effects and the prevention of contrast-induced nephropathy by atrial natriuretic peptide.

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March 1, 2009

Nephrotoxicity of iso-osmolar iodixanol compared with nonionic low-osmolar contrast media: meta-analysis of randomized controlled trials.

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February 1, 2009

Sodium bicarbonate to prevent increases in serum creatinine after cardiac surgery: a pilot double-blind, randomized controlled trial.

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February 1, 2009

Meta-analysis of N-acetylcysteine to prevent acute renal failure after major surgery.

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September 1, 2008

Sodium bicarbonate vs sodium chloride for the prevention of contrast medium-induced nephropathy in patients undergoing coronary angiography: a randomized trial.

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September 1, 2008

Iso-Osmolality versus Low-Osmolality Iodinated Contrast Medium at Intravenous Contrast-enhanced CT: Effect on Kidney Function

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March 1, 2008

Meta-analysis: effectiveness of drugs for preventing contrast-induced nephropathy.

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February 1, 2008

Sodium bicarbonate is associated with an increased incidence of contrast nephropathy: a retrospective cohort study of 7977 patients at mayo clinic.

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5 Comments Posted in Contrast Nephropathy
July 1, 2007

Trimetazidine in the prevention of contrast-induced nephropathy after coronary procedures.

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