Archive for the ‘Diabetes’ Category

August 14, 2016

Empagliflozin and Progression of Kidney Disease in Type 2 Diabetes

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  This randomized control trial of over 4000 high risk patients with Type 2 diabetes and eGFR > 30 ml/min, empagliflozin (a sodium-glucose cotransporter 2 inhibitor) when compared with placebo was associated with slower progression of kidney disease (12.7% vs 18.8% for worsening nephropathy and 1.5% vs 2.6% for doubling of serum creatinine) when added to the standard of care.  […]

No Comments Posted in Chronic Kidney Disease, Clinical Nephrology, Clinical Trial Results, Diabetes, General Nephrology
November 30, 2015

Serum Uric Acid and Risk of CKD in Type 2 Diabetes.

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This longitudinal study of a cohort of patients with type 2 diabetes from the database of the Italian Association of Clinical Diabetologists network. Urinary albumin excretion, GFR, and serum uric acid were available in 13,964 patients. They further assessed the association of serum uric acid quintiles with onset of CKD components by multinomial logistic regression model adjusting for potential confounders. At 4-year follow-up, the […]

No Comments Posted in Chronic Kidney Disease, Clinical Nephrology, Clinical Trial Results, Diabetes
November 10, 2015

Empagliflozin and Clinical Outcomes in Patients with Type 2 Diabetes and Chronic Kidney Disease

These are results as presented at the 2015 American Society of Nephrology Kidney Week. The effect of empagliflozin vs placebo on cardiovascular events and death was recently reported in the NEJM in Sep 2015, and shown to significantly reduce both the composite cardiovascular primary endpoint and death. During Kidney Week, the renal outcome of new […]

No Comments Posted in Chronic Kidney Disease, Diabetes, General Nephrology
September 21, 2015

Electrolyte and Acid–Base Disturbances in Patients with Diabetes Mellitus

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This review nicely summarizes electrolyte and acid-base base abnormalities and their management in patients with diabetes.

No Comments Posted in Clinical Nephrology, Diabetes, Fluid & Electrolytes, General Nephrology
January 24, 2015

Metformin in Patients With Type 2 Diabetes and Kidney Disease: A Systematic Review

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This review nicely summarizes the risks of metformin therapy in patients with mild to moderate chronic kidney disease.  According to the authors, there is room for “cautious expansion” of use in this population.

No Comments Posted in Clinical Nephrology, Diabetes
November 16, 2014

Follow-up of Blood-Pressure Lowering and Glucose Control in Type 2 Diabetes

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In this 6-year follow-up study of patients enrolled in ADVANCE, there was no evidence that intensive glucose control during the trial led to long-term benefits with respect to mortality or macrovascular events. Though event rates were small, there was a reduction in end-stage renal disease in those patients in the intensive glucose arm, hazard ratio 0.54; […]

No Comments Posted in Chronic Kidney Disease, Diabetes
December 21, 2013

Diet and Kidney Disease in High-Risk Individuals With Type 2 Diabetes Mellitus

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This observational study of the ONTARGET type 2 diabetic patient population showed that a healthy diet (consisting of more than 3 servings of fruit per week) and a moderate intake of alcohol may decrease the incidence or progression of CKD in this population. Interestingly, sodium and normal protein intake were not associated with CKD.

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September 8, 2013

Risks and benefits of intensive blood pressure lowering in patients with type 2 diabetes

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This review discusses the basis for the blood pressure target of < 130/80 mm Hg for patients with hypertension and diabetes.

1 Comment Posted in Diabetes, Hypertension
January 28, 2013

Body Mass Index in 1.2 Million Adolescents and Risk for End-Stage Renal Disease

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This population-based retrospective cohort study linked medical data from military service fitness examinations to the Israeli ESRD registry to determine if there is a link between BMI and development of ESRD. Over 1 million adolescents age 17 years underwent a fitness examinations from 1967-1997. This was linked to incident treated cases of ESRD from 1980 […]

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November 4, 2012

Cardiorenal End Points in a Trial of Aliskiren for Type 2 Diabetes

As we originally reported towards the end of 2011, the ALTITUDE trial was terminated early.  The data from this trial was reported on November 3, 2012 at the American Society of Nephrology Kidney Week by Dr. Parving and simultaneously published online by the New England Journal of Medicine. In ALTITUDE, a double-blind, randomized controlled trial, patients […]

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July 8, 2012

2012 infectious diseases society of america clinical practice guideline for the diagnosis and treatment of diabetic foot infections.

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Nephrologists frequently encounter diabetic foot infections in their patients. This clinical practice guideline from the IDSA is a useful tool that supports management of this common problem.

Comments Off on 2012 infectious diseases society of america clinical practice guideline for the diagnosis and treatment of diabetic foot infections. Posted in Diabetes, Internal Medicine for Nephrologists
November 12, 2011

Intensive Diabetes Therapy and Glomerular Filtration Rate in Type 1 Diabetes

This paper was published online in the New England Journal of Medicine paper in order to coincide with the oral presentation at the 2011 American Society of Nephrology meeting. This report describes renal follow-up of Type 1 diabetic patients enrolled in the DCCT (Diabetes Control and Complications Trial) and EDIC (Epidemiology of Diabetes Interventions and Complications) […]

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June 24, 2011

Bardoxolone Methyl and Kidney Function in CKD with Type 2 Diabetes

Free full text available for several days only.  This industry-sponsored phase 2 RCT examined the impact of  bardoxolone methyl, an oral antioxidant inflammation modulator, on renal function in patients with CKD and diabetes.  At 24 and 52 weeks, the intervention arms had improved eGFR compared to placebo.  Hard clinical endpoints were not examined in this study.

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