August 14, 2016
This randomized control trial of over 4000 high risk patients with Type 2 diabetes and eGFR > 30 ml/min, empagliflozin (a sodium-glucose cotransporter 2 inhibitor) when compared with placebo was associated with slower progression of kidney disease (12.7% vs 18.8% for worsening nephropathy and 1.5% vs 2.6% for doubling of serum creatinine) when added to the standard of care. […]
November 30, 2015
This longitudinal study of a cohort of patients with type 2 diabetes from the database of the Italian Association of Clinical Diabetologists network. Urinary albumin excretion, GFR, and serum uric acid were available in 13,964 patients. They further assessed the association of serum uric acid quintiles with onset of CKD components by multinomial logistic regression model adjusting for potential confounders. At 4-year follow-up, the […]
November 10, 2015
These are results as presented at the 2015 American Society of Nephrology Kidney Week. The effect of empagliflozin vs placebo on cardiovascular events and death was recently reported in the NEJM in Sep 2015, and shown to significantly reduce both the composite cardiovascular primary endpoint and death. During Kidney Week, the renal outcome of new […]
September 21, 2015
This review nicely summarizes electrolyte and acid-base base abnormalities and their management in patients with diabetes.
January 24, 2015
This review nicely summarizes the risks of metformin therapy in patients with mild to moderate chronic kidney disease. According to the authors, there is room for “cautious expansion” of use in this population.
November 16, 2014
In this 6-year follow-up study of patients enrolled in ADVANCE, there was no evidence that intensive glucose control during the trial led to long-term benefits with respect to mortality or macrovascular events. Though event rates were small, there was a reduction in end-stage renal disease in those patients in the intensive glucose arm, hazard ratio 0.54; […]
December 21, 2013
This observational study of the ONTARGET type 2 diabetic patient population showed that a healthy diet (consisting of more than 3 servings of fruit per week) and a moderate intake of alcohol may decrease the incidence or progression of CKD in this population. Interestingly, sodium and normal protein intake were not associated with CKD.
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Posted in Chronic Kidney Disease, Clinical Nephrology, Diabetes
September 8, 2013
This review discusses the basis for the blood pressure target of < 130/80 mm Hg for patients with hypertension and diabetes.
January 28, 2013
This population-based retrospective cohort study linked medical data from military service fitness examinations to the Israeli ESRD registry to determine if there is a link between BMI and development of ESRD. Over 1 million adolescents age 17 years underwent a fitness examinations from 1967-1997. This was linked to incident treated cases of ESRD from 1980 […]
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Posted in Chronic Kidney Disease, Clinical Trial Results, Diabetes
November 4, 2012
As we originally reported towards the end of 2011, the ALTITUDE trial was terminated early. The data from this trial was reported on November 3, 2012 at the American Society of Nephrology Kidney Week by Dr. Parving and simultaneously published online by the New England Journal of Medicine. In ALTITUDE, a double-blind, randomized controlled trial, patients […]
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Posted in Diabetes, RAS Blockade
July 8, 2012
Nephrologists frequently encounter diabetic foot infections in their patients. This clinical practice guideline from the IDSA is a useful tool that supports management of this common problem.
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Posted in Diabetes, Internal Medicine for Nephrologists
November 12, 2011
This paper was published online in the New England Journal of Medicine paper in order to coincide with the oral presentation at the 2011 American Society of Nephrology meeting. This report describes renal follow-up of Type 1 diabetic patients enrolled in the DCCT (Diabetes Control and Complications Trial) and EDIC (Epidemiology of Diabetes Interventions and Complications) […]
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Posted in Clinical Trial Results, Diabetes
June 24, 2011
Free full text available for several days only. This industry-sponsored phase 2 RCT examined the impact of bardoxolone methyl, an oral antioxidant inflammation modulator, on renal function in patients with CKD and diabetes. At 24 and 52 weeks, the intervention arms had improved eGFR compared to placebo. Hard clinical endpoints were not examined in this study.
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Posted in Chronic Kidney Disease, Diabetes