Archive for the ‘Diabetes’ Category

April 24, 2011

Long-term Renal Outcomes of Patients With Type 1 Diabetes Mellitus and Microalbuminuria

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This study is a long-term follow-up of patients with microalbuminuria enrolled in the DCCT/EDIC trial.  After a median follow-up of 13 years, intensive glycemic control, lower blood pressure, and improved lipid profile were associated with improved clinical outcomes.

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May 1, 2010

Effect of B-Vitamin Therapy on Progression of Diabetic Nephropathy

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This RCT examined compared a strategy of homocysteine reduction using folic acid, vitamin B6, and vitamin B12 versus placebo in patient with diabetic nephropathy. The active therapy arm experienced a greater decrease in GFR and an increase in vascular events.

3 Comments Posted in Chronic Kidney Disease, Diabetes
May 1, 2010

Effect of Valsartan on the Incidence of Diabetes and Cardiovascular Events

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9306 patients with IGTT and established cardiovascular disease or cardiovascular risk factors were randomized to receive valsartan (up to 160 mg daily) or placebo (and nateglinide or placebo) in addition to lifestyle modification. After a median 5 year follow-up, there was a relative reduction of 14% in the incidence of diabetes in the valsartan group. […]

1 Comment Posted in Diabetes, RAS Blockade
March 23, 2010

Effect of Valsartan on the Incidence of Diabetes and Cardiovascular Events

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This RCT randomized patients with impaired glucose tolerance and established cardiovascular disease or cardiovascular risk factors to receive valsartan (up to 160 mg daily) or placebo in addition to lifestyle modification. No reduction in cardiovascular events was noted at 5 years, but the incidence of diabetes was reduced; 33.1% in the valsartan group vs 36.8% […]

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March 23, 2010

Effects of Intensive Blood-Pressure Control in Type 2 Diabetes Mellitus

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In the ACCORD BP study, patients with type 2 diabetes at high risk for cardiovascular events were randomized to a target systolic blood pressure of <120 mmHg vs <140 mmHg. After 4.7 years, there was no significant difference in cardiovascular events or mortality but there was an increase in serious adverse events related to anti-hypertensive […]

1 Comment Posted in Diabetes, Hypertension
March 1, 2009

Design of combination angiotensin receptor blocker and angiotensin-converting enzyme inhibitor for treatment of diabetic nephropathy (VA NEPHRON-D).

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March 1, 2009

Avosentan reduces albumin excretion in diabetics with macroalbuminuria.

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September 1, 2008

The Effect of Pentoxifylline on Proteinuria in Diabetic Kidney Disease: A Meta-analysis.

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May 1, 2008

Effect of a multifactorial intervention on mortality in type 2 diabetes.

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February 1, 2008

Efficacy of cholesterol-lowering therapy in 18,686 people with diabetes in 14 randomised trials of statins: a meta-analysis.

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January 1, 2008

Kidney disease in diabetology: lessons from 2008.

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December 1, 2007

Rosiglitazone decreases albuminuria in type 2 diabetic patients.

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November 1, 2007

Management of Glycemia in Patients With Diabetes Mellitus and CKD.

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Comments Off on Management of Glycemia in Patients With Diabetes Mellitus and CKD. Posted in Diabetes