Archive for the ‘General Nephrology’ Category

November 30, 2015

A randomized trial of intravenous and oral iron in chronic kidney disease.

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This trial randomly assigned patients with stage 3 and 4 CKD and IDA to either open-label oral ferrous sulfate (69 patients to 325 mg three times daily for 8 weeks) or intravenous iron sucrose (67 patients to 200 mg every 2 weeks, total 1 g). The trial was terminated early on the recommendation of an independent data and safety due to higher risk of serious […]

No Comments Posted in Chronic Kidney Disease, Clinical Trial Results, General Nephrology
November 10, 2015

Randomized Trial on Efficacy of Mycophenolate Mofeti versus Tacrolimus in Maintaining Remission in Children with Steroid Resistant Nephrotic Syndrome

These are results as presented at the 2015 American Society of Nephrology Kidney Week. In children with steroid resistant nephrotic syndrome who were successfully put into remission, maintenance therapy with MMF 750-1000 mg/m2was compared to tacrolimus 0.1-0.15 mg/kg/day. The primary endpoint of preserved complete or partial remission was achieved in 90.3% of the tacrolimus arm […]

No Comments Posted in General Nephrology
November 10, 2015

Empagliflozin and Clinical Outcomes in Patients with Type 2 Diabetes and Chronic Kidney Disease

These are results as presented at the 2015 American Society of Nephrology Kidney Week. The effect of empagliflozin vs placebo on cardiovascular events and death was recently reported in the NEJM in Sep 2015, and shown to significantly reduce both the composite cardiovascular primary endpoint and death. During Kidney Week, the renal outcome of new […]

No Comments Posted in Chronic Kidney Disease, Diabetes, General Nephrology
September 21, 2015

Peri-procedural management of patients taking oral anticoagulants

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Nephrology patients often require many procedures.  It is important that their physicians know how to mitigate the risks of anticoagulation therapy especially in the era of novel agents.  This article will help guide physician to better provide peri-procedural management of oral anticoagulation therapy.

No Comments Posted in General Nephrology, Review
September 21, 2015

Electrolyte and Acid–Base Disturbances in Patients with Diabetes Mellitus

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This review nicely summarizes electrolyte and acid-base base abnormalities and their management in patients with diabetes.

No Comments Posted in Clinical Nephrology, Diabetes, Fluid & Electrolytes, General Nephrology
July 13, 2015

Current treatment practice and outcomes. Report of the hyponatremia registry

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This report from the hyponatremia registry highlights the multifaceted and often clinically disparate approach to the management of hyponatremia.  Interestingly, most patients were discharged from hospital still hyponatremic.          

Comments Off on Current treatment practice and outcomes. Report of the hyponatremia registry Posted in Clinical Nephrology, Fluid & Electrolytes, General Nephrology
July 13, 2015

Kidney function and the use of nitrofurantoin to treat urinary tract infections in older women

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This population-based study of older woman (mean age > 79 years) in Ontario, Canada showed that lower eGFR (median 38 ml/min per 1.73 m2) vs higher eGFR (median 69 ml/min per 1.73 m2) was not associated with an increased risk of urinary tract infection treatment failure with nitrofurantoin.  

Comments Off on Kidney function and the use of nitrofurantoin to treat urinary tract infections in older women Posted in Clinical Nephrology, General Nephrology
May 8, 2015

Continuous Proton Pump Inhibitor Therapy and the Associated Risk of Recurrent Clostridium difficileInfection

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This retrospective cohort study found that patients on proton pump inhibitors were at higher risk of C. difficile infections after adjustment for other independent risk factors for recurrence. This important study highlights the importance of medication review – which suggests consideration of discontinuation of PPIs at the time of CDI diagnosis. PMID:25730198

Comments Off on Continuous Proton Pump Inhibitor Therapy and the Associated Risk of Recurrent Clostridium difficileInfection Posted in General Nephrology
May 8, 2015

Molecular physiology of water balance

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This review describes the recent progress in understanding the roles of selected gene products in the regulation of water balance and their relevance in clinical practice.    

Comments Off on Molecular physiology of water balance Posted in Clinical Nephrology, Fluid & Electrolytes, General Nephrology
March 18, 2015

Less-Tight versus Tight Control of Hypertension in Pregnancy

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This open, multicentre trial assigned women with nonproteinuric or gestatational hypertension to less tight control (target diastolic BP 100 mmHg) vs tight control (target diastolic BP 85 mmHg) with no difference observed in the primary outcome of pregnancy loss, high level neonatal care or overall maternal complications (secondary outcome).  However, the less tight control group […]

Comments Off on Less-Tight versus Tight Control of Hypertension in Pregnancy Posted in Clinical Nephrology, Clinical Trial Results, General Nephrology, Hypertension, Pregnancy and Hypertension/Renal Disease
March 18, 2015

Acid–Base Problems in Diabetic Ketoacidosis

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This review focuses on three issues facing clinicians who care for patients with diabetic ketoacidosis: (1) the plasma anion gap, (2) the administration of sodium bicarbonate and (3) the possible contribution of intracellular acidosis to the development of cerebral edema.

Comments Off on Acid–Base Problems in Diabetic Ketoacidosis Posted in Clinical Nephrology, Fluid & Electrolytes, General Nephrology, Review
March 18, 2015

Trimethoprim-sulfamethoxazole and risk of sudden death among patients taking spironolactone

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Compared with amoxicillin, trimethoprim-sulfamethoxazole was associated with a  twofold increase of sudden death (adjusted OR 2.46, 95 % CI 1.55-3.90) as a consequence of hyperkalemia in this population-based study of patients over the age of 65 on spironolactone.

Comments Off on Trimethoprim-sulfamethoxazole and risk of sudden death among patients taking spironolactone Posted in Clinical Nephrology, Fluid & Electrolytes, General Nephrology
March 18, 2015

Emerging treatments for amyloidosis

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This review briefs us on the novel approaches for the treatment of amyloidosis.  These targeted therapies may be better options for a disease that frequently has a very poor prognosis.

Comments Off on Emerging treatments for amyloidosis Posted in Acute Kidney Injury, Clinical Nephrology, General Nephrology, Review