Archive for the ‘Lupus’ Category

August 14, 2016

Lupus nephritis management guidelines compared

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This review summarizes the 6 difference guidelines for treatment lupus nephritis – the commonalities, differences as well as highlights the recent literature.    

No Comments Posted in Clinical Nephrology, Clinical Practice Guidelines, Glomerulonephritis, Lupus
September 8, 2013

The Pathogenesis of Lupus Nephritis

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This review goes into extensive detail on the pathogenesis of lupus nephritis and provides the rationale for treatment. Full text kindly provided by the American Society of Nephrology.

1 Comment Posted in Lupus, Review
July 14, 2013

Mycophenolate Mofetil or Intravenous Cyclophosphamide for Lupus Nephritis With Poor Kidney Function: A Subgroup Analysis of the Aspreva Lupus Management Study

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This post hoc subgroup analysis of the ALMS trial (comparing MMF to cyclophosphamide in lupus nephritis) specifically assessed patients with GFR < 30 ml/min/1.73m2. No difference was detected in the primary outcome of response to treatment (decrease in proteinuria and stabilization or improvement of serum creatinine level). The accompanying editorial asks whether post-hoc subgroup analyses […]

3 Comments Posted in Lupus
July 14, 2013

Impact of the ALMS and MAINTAIN trials on the management of lupus nephritis

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This review discusses how ALMS and MAINTAIN guide the choice of maintenance therapy in lupus nephritis, as well as drug dosing and total duration of therapy.

2 Comments Posted in Lupus, Review
November 29, 2011

Mycophenolate versus Azathioprine as Maintenance Therapy for Lupus Nephritis

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This 3-year randomized controlled trial compared mycophenolate mofetil and azathioprine as maintenance therapy after induction of remission in lupus nephritis.  Mycophenolate mofetil was superior to azathioprine in achieving the primary end point, time to treatment failure, time to renal flare and time to rescue therapy  There was a trend to fewer serious adverse events in […]

Comments Off on Mycophenolate versus Azathioprine as Maintenance Therapy for Lupus Nephritis Posted in Lupus
February 8, 2011

Short-term Outcomes of Induction Therapy With Tacrolimus Versus Cyclophosphamide for Active Lupus Nephritis: A Multicenter Randomized Clinical Trial

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This multicenter noninferiority randomized controlled trial compared the efficacy and safety of tacrolimus versus intravenous cyclophosphamide as induction therapy for lupus nephritis. While limited by lack of blinding, small sample size, and short duration of follow-up, this study suggested that prednisone + tacrolimus achieved similar cumulative probabilities of complete remission and response than prednisone + […]

Comments Off on Short-term Outcomes of Induction Therapy With Tacrolimus Versus Cyclophosphamide for Active Lupus Nephritis: A Multicenter Randomized Clinical Trial Posted in Lupus
December 26, 2010

Updates on the Treatment of Lupus Nephritis

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This excellent review of lupus nephritis focuses on summarizing the most effective treatment for this condition while limiting therapy-induced toxicity. Free full text kindly provided by ASN.

Comments Off on Updates on the Treatment of Lupus Nephritis Posted in Lupus, Review
January 11, 2010

Mycophenolate mofetil and intravenous cyclophosphamide are similar as induction therapy for class V lupus nephritis

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Results of two randomized trial using induction treatment with either MMF or intravenous cyclophosphamide were pooled in this article. At 24 weeks, the results show that both groups were similar with respect to percentage change in proteinuria and serum creatinine as end points when used to treat patients with class V lupus.

Comments Off on Mycophenolate mofetil and intravenous cyclophosphamide are similar as induction therapy for class V lupus nephritis Posted in Glomerulonephritis, Lupus
October 18, 2009

Mycophenolate mofetil is as efficacious as, but safer than, cyclophosphamide in the treatment of proliferative lupus nephritis: a meta-analysis and meta-regression.

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This meta-analysis suggests that for the treatment of proliferative lupus nephritis, MMF offers similar efficacy in renal remission and survival as cyclophosphamide with a better safety profile.

Comments Off on Mycophenolate mofetil is as efficacious as, but safer than, cyclophosphamide in the treatment of proliferative lupus nephritis: a meta-analysis and meta-regression. Posted in Glomerulonephritis, Lupus
July 10, 2009

Rituximab and mycophenolate mofetil for relapsing proliferative lupus nephritis: a long-term prospective study

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This prospective, observational study looked 10 women with subnephrotic proliferative lupus nephritis who relapsed on maintenance MMF or Imuran. They were treated with 4 weekly infusions of rituximab combined with MMF and prednisolone. This combination was found to have low toxicity and 7 patients were found to have a complete remission. This seems to warrant […]

1 Comment Posted in Glomerulonephritis, Lupus
May 2, 2009

Mycophenolate mofetil versus cyclophosphamide for induction treatment of lupus nephritis.

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This study randomized 370 patients with class III to V lupus nephritis to MMF or intravenous cyclophosphamide during a 24-week induction period. Both groups received a tapering dose of prednisone. No difference in response rate was detected between groups.

Comments Off on Mycophenolate mofetil versus cyclophosphamide for induction treatment of lupus nephritis. Posted in Lupus
April 1, 2009

Randomized, Controlled Trial of Prednisone, Cyclophosphamide, and Cyclosporine in Lupus Membranous Nephropathy.

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This study randomized patients with lupus membranous nephropathy to prednisone, cyclophosphamide or cyclosporine. Regimens containing cyclosporine or cyclophosphamide were each more effective than prednisone alone in inducing remission of proteinuria among such patients.

Comments Off on Randomized, Controlled Trial of Prednisone, Cyclophosphamide, and Cyclosporine in Lupus Membranous Nephropathy. Posted in Lupus
April 1, 2009

Treatment of Membranous Lupus Nephritis: Where Are We Now?

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Comments Off on Treatment of Membranous Lupus Nephritis: Where Are We Now? Posted in Lupus