November 22, 2009
ASTRAL Investigators, Wheatley K, Ives N, Gray R, Kalra PA, Moss JG, Baigent C, Carr S, Chalmers N, Eadington D, Hamilton G, Lipkin G, Nicholson A, Scoble J. N Engl J Med. 2009 Nov 12;361(20):1953-62
This randomized, non-blinded study of patients with renovascular disease compared renal artery revascularization plus medical therapy vs medical therapy alone. Â Those in the revascularization arm experience an increased rate of serious complications with no reduction in pre-defined clinical endpoints.
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May 2, 2009
Bax L, Woittiez AJ, Kouwenberg HJ, Mali WP, Buskens E, Beek FJ, Braam B, Huysmans FT, Schultze Kool LJ, Rutten MJ, Doorenbos CJ, Aarts JC, Rabelink TJ, Plouin PF, Raynaud A, van Montfrans GA, Reekers JA, van den Meiracker AH, Pattynama PM, van de Ven PJ, Vroegindeweij D, Kroon AA, de Haan MW, Postma CT, Beutler JJ. Ann Intern Med. 2009 Jun 16;150(12):840-8, W150-1
140 patients were randomized to determine the efficacy and safety of stent placement in patients with atherosclerotic renal artery stenosis and impaired renal function. The study concluded that stent placement with medical treatment had no clear effect on progression of renal dysfunction and, therefore, favored a conservative approach with cardiovascular risk factor management without stenting.
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