Archive for the ‘Renal Transplantation’ Category

July 13, 2015

A simple clinical tool to inform the decision-making process to refer elderly incident dialysis patients for kidney transplant evaluation

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Using data from the French national prospective registry, the authors developed and validated a clinical screening score to identify ESRD patients over the age of 70 years with an acceptable prognosis and hence most suitable for kidney transplantation. This scoring card can be helping to the practicing nephrologist to select suitable patients over the age […]

No Comments Posted in Clinical Nephrology, Clinical Trial Results, Hemodialysis, Renal Transplantation
July 13, 2015

Long-term medical risks to the living kidney donor

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This review nicely summarizes the studies that assess long-term medical outcomes for living kidney donors.  Although the focus is on the first 10 years, the authors also note that further studies need to be conducted to better assess risk in certain populations.        

No Comments Posted in Renal Transplantation, Review
November 16, 2014

Gestational Hypertension and Preeclampsia in Living Kidney Donors

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This retrospective cohort study showed an increased risk of gestational hypertension or preeclampsia in women who have been living kidney donors, 11% in donors vs 5% in non-donors (OR 2.4; 95% CI, 1.2 to 5.0; P=0.01).

No Comments Posted in Pregnancy and Hypertension/Renal Disease, Renal Transplantation
April 19, 2014

Risk of End-Stage Renal Disease Following Live Kidney Donation

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This study compare the risk of developing ESRD in kidney donors to that of similarly screened healthy nondonors (a cohort of NHANES III participants). The results show estimated lifetime risk of ESRD was 90 per 10 000 donors, 326 per 10 000 unscreened nondonors (general population), and 14 per 10 000 healthy nondonors.

Comments Off on Risk of End-Stage Renal Disease Following Live Kidney Donation Posted in Chronic Kidney Disease, Clinical Trial Results, Renal Transplantation
January 28, 2013

Common infections in kidney transplant recipients.

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This article reviews common post-transplant infections, including prophylactic, diagnostic, and treatment strategies.

Comments Off on Common infections in kidney transplant recipients. Posted in Renal Transplantation
September 18, 2012

Cardiac Disease Evaluation and Management Among Kidney and Liver Transplantation Candidates

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This guideline from the American Heart Association and the American College of Cardiology reviews preoperative cardiac evaluation in renal transplant candidates.

Comments Off on Cardiac Disease Evaluation and Management Among Kidney and Liver Transplantation Candidates Posted in Renal Transplantation
September 18, 2012

Acute dialysis risk in living kidney donors

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This is a population-based matched cohort study of all living kidney donors in Ontario, Canada form 1992-2009. Of the 2027 donors and 20 270 matched non-donors reviewed only 1 donor required acute dialysis in the 6 year follow-up. This was not statistically significant from the non-donor rate. This study adds further reassuring evidence for the […]

Comments Off on Acute dialysis risk in living kidney donors Posted in Acute Kidney Injury, Clinical Nephrology, Renal Transplantation
July 8, 2012

The Case for Kidney Donation Before End-of-Life Care

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This article, and the 6 open peer commentaries that accompany it, discusses whether ante mortem donation of kidneys is ethically feasible in those patients in whom a decision has been made to discontinue life sustaining therapy. The authors argue that this strategy is ethically equivalent to donation after cardiac death, since the ante mortem removal […]

Comments Off on The Case for Kidney Donation Before End-of-Life Care Posted in Renal Transplantation
July 8, 2012

Leflunomide Efficacy and Pharmacodynamics for the Treatment of BK Viral Infection

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Leflunomide has been proposed as a replacement for mycophenolic acid in patients with BK nephropathy, as it has immunosuppressive properties and activity against BK in vitro. In this retrospective study, there was no correlation between leflunomide metabolite levels and clearance of BK viremia. This study highlights the need for well-designed randomized controlled trials to determine […]

Comments Off on Leflunomide Efficacy and Pharmacodynamics for the Treatment of BK Viral Infection Posted in Renal Transplantation
July 8, 2012

Randomized Phase 2b Trial of Tofacitinib (CP-690,550) in De Novo Kidney Transplant Patients: Efficacy, Renal Function and Safety at 1 Year

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Tofacitinib is the first in a new class of immunosuppressive agents that inhibit janus kinase, an important transcription factor. This randomized-controlled trial compared tofacitinib to cyclosporine in renal transplant patients. Tofacitinib showed lower rates of acute rejection and chronic changes on biopsy, with better renal function compared to a cyclosporine-based regimen. On the other hand, […]

Comments Off on Randomized Phase 2b Trial of Tofacitinib (CP-690,550) in De Novo Kidney Transplant Patients: Efficacy, Renal Function and Safety at 1 Year Posted in Renal Transplantation
July 8, 2012

Post-transplant malignancy: reducing the risk in kidney transplant recipients

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Post-transplant malignancy, one of the most common causes of death following transplantation, is linked to both modifiable and non-modifiable risk factors. This publication reviews the scope of the problem of post-transplant malignancy, its pathogenesis, and strategies for prevention, with attention to the impact of various immunosuppressive strategies. The systematic review included a Medline search of […]

Comments Off on Post-transplant malignancy: reducing the risk in kidney transplant recipients Posted in Renal Transplantation
July 8, 2012

Randomized Trial of Short-Course High-Dose Erythropoietin in Donation After Cardiac Death Kidney Transplant Recipients

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Donation after cardiac death (DCD) donors have become an important source of organs, but the rates of delayed graft function (DGF) remains high. Erythropoietin may protect against schema-reperfusion injury. In this randomized controlled trial, erythropoietin or placebo was given to recipients of DCD kidneys. There was no difference in DGF rates, acute rejection, or renal […]

Comments Off on Randomized Trial of Short-Course High-Dose Erythropoietin in Donation After Cardiac Death Kidney Transplant Recipients Posted in Renal Transplantation
July 8, 2012

Tolerance and Withdrawal of Immunosuppressive Drugs in Patients Given Kidney and Hematopoietic Cell Transplants

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While tolerance is one of the ultimate goals for transplantation, there have been few studies rigorously attempting tolerogenic protocols. This paper reports the results of an attempt to induce tolerance using a combination of total lymphoid radiation, thymoglobulin and donor bone-marrow cell infusion in recipients of very closely HLA-matched kidneys. Immunosuppression was completely withdrawn in […]

Comments Off on Tolerance and Withdrawal of Immunosuppressive Drugs in Patients Given Kidney and Hematopoietic Cell Transplants Posted in Renal Transplantation