Nephrology Now » Vasculitis http://www.nephrologynow.com Sat, 28 Jan 2012 08:32:30 +0000 en hourly 1 http://wordpress.org/?v=3.3.1 Prolonged disease-free remission following rituximab and low-dose cyclophosphamide therapy for renal ANCA-associated vasculitis http://www.nephrologynow.com/publications/prolonged-disease-free-remission-following-rituximab-and-low-dose-cyclophosphamide-therapy-for-renal-anca-associated-vasculitis http://www.nephrologynow.com/publications/prolonged-disease-free-remission-following-rituximab-and-low-dose-cyclophosphamide-therapy-for-renal-anca-associated-vasculitis#comments Tue, 29 Nov 2011 07:20:48 +0000 Nephrology Now editors http://www.nephrologynow.com/?p=2132 This study of twenty-three patients presenting or relapsing with ANCA-associated vasculitis were treated with two pulses of rituximab 2 weeks apart, six biweekly doses of cyclophosphamide and a tapering course of oral steroids. They were subsequently put on a maintenance regimen of low-dose steroids and azathioprine.  All patients achieved clinical remission within six weeks. Five [...]]]>
This study of twenty-three patients presenting or relapsing with ANCA-associated vasculitis were treated with two pulses of rituximab 2 weeks apart, six biweekly doses of cyclophosphamide and a tapering course of oral steroids. They were subsequently put on a maintenance regimen of low-dose steroids and azathioprine.  All patients achieved clinical remission within six weeks. Five patients relapsed at a median of 30 months.  Adverse events included one severe drug reaction and one serious infection.  This regimen may be considered in the creation of steroid minimizing regimen.

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]]> http://www.nephrologynow.com/publications/prolonged-disease-free-remission-following-rituximab-and-low-dose-cyclophosphamide-therapy-for-renal-anca-associated-vasculitis/feed 0 Maintenance Immunosuppression in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis http://www.nephrologynow.com/publications/maintenance-immunosuppression-in-antineutrophil-cytoplasmic-antibody%e2%80%93associated-vasculitis http://www.nephrologynow.com/publications/maintenance-immunosuppression-in-antineutrophil-cytoplasmic-antibody%e2%80%93associated-vasculitis#comments Wed, 15 Jun 2011 06:58:22 +0000 Nephrology Now editors http://www.nephrologynow.com/?p=2005 This review provides commentary on the article ‘Mycophenolate mofetil vs azathioprine for remission maintenance in antineutrophil cytoplasmic antibody-associated vasculitis: a randomized controlled trial.’, authored by Hiemstra TF, Walsh M, Mahr A, et al for the European Vasculitis Study Group (EUVAS). Related Articles: Therapeutic Interventions for Systemic Vasculitis Mycophenolate versus Azathioprine as Maintenance Therapy for Lupus [...]]]>

This review provides commentary on the article ‘Mycophenolate mofetil vs azathioprine for remission maintenance in antineutrophil cytoplasmic antibody-associated vasculitis: a randomized controlled trial.’, authored by Hiemstra TF, Walsh M, Mahr A, et al for the European Vasculitis Study Group (EUVAS).

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]]> http://www.nephrologynow.com/publications/maintenance-immunosuppression-in-antineutrophil-cytoplasmic-antibody%e2%80%93associated-vasculitis/feed 0 Mycophenolate Mofetil vs Azathioprine for Remission Maintenance in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A Randomized Controlled Trial http://www.nephrologynow.com/publications/mycophenolate-mofetil-vs-azathioprine-for-remission-maintenance-in-antineutrophil-cytoplasmic-antibody-associated-vasculitis-a-randomized-controlled-trial http://www.nephrologynow.com/publications/mycophenolate-mofetil-vs-azathioprine-for-remission-maintenance-in-antineutrophil-cytoplasmic-antibody-associated-vasculitis-a-randomized-controlled-trial#comments Tue, 09 Nov 2010 05:03:29 +0000 Nephrology Now editors http://www.nephrologynow.com/?p=1686 In this publication by the EUVAS group, mycophenolate mofetil was found to be less effective than azathioprine for maintaining disease remission in ANCA-associated vasculitis. Free full text provided by JAMA. Related Articles: Therapeutic Interventions for Systemic Vasculitis Maintenance Immunosuppression in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis Mycophenolate versus Azathioprine as Maintenance Therapy for Lupus Nephritis]]>
In this publication by the EUVAS group, mycophenolate mofetil was found to be less effective than azathioprine for maintaining disease remission in ANCA-associated vasculitis.

Free full text provided by JAMA.

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]]> http://www.nephrologynow.com/publications/mycophenolate-mofetil-vs-azathioprine-for-remission-maintenance-in-antineutrophil-cytoplasmic-antibody-associated-vasculitis-a-randomized-controlled-trial/feed 0 Therapeutic Interventions for Systemic Vasculitis http://www.nephrologynow.com/publications/therapeutic-interventions-for-systemic-vasculitis http://www.nephrologynow.com/publications/therapeutic-interventions-for-systemic-vasculitis#comments Tue, 09 Nov 2010 05:02:35 +0000 Nephrology Now editors http://www.nephrologynow.com/?p=1682 This editorial provides critical analysis and commentary on the article ‘Mycophenolate Mofetil vs Azathioprine for Remission Maintenance in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A Randomized Controlled Trial’. Free full text provided by JAMA. Related Articles: Maintenance Immunosuppression in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis Mycophenolate Mofetil vs Azathioprine for Remission Maintenance in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A Randomized Controlled Trial Mycophenolate [...]]]>
This editorial provides critical analysis and commentary on the article ‘Mycophenolate Mofetil vs Azathioprine for Remission Maintenance in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A Randomized Controlled Trial’.

Free full text provided by JAMA.

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]]> http://www.nephrologynow.com/publications/therapeutic-interventions-for-systemic-vasculitis/feed 0 Rituximab versus Cyclophosphamide in ANCA-Associated Renal Vasculitis http://www.nephrologynow.com/publications/rituximab-versus-cyclophosphamide-in-anca-associated-renal-vasculitis http://www.nephrologynow.com/publications/rituximab-versus-cyclophosphamide-in-anca-associated-renal-vasculitis#comments Tue, 20 Jul 2010 07:46:28 +0000 Nephrology Now editors http://www.nephrologynow.com/?p=1547 This RCT did not find that a rituximab-based regimen was superior to standard intravenous cyclophosphamide for severe ANCA-associated vasculitis. Related Articles: Rituximab versus Cyclophosphamide for ANCA-Associated Vasculitis Prolonged disease-free remission following rituximab and low-dose cyclophosphamide therapy for renal ANCA-associated vasculitis Pulse versus daily oral cyclophosphamide for induction of remission in antineutrophil cytoplasmic antibody—associated vasculitis.]]>
This RCT did not find that a rituximab-based regimen was superior to standard intravenous cyclophosphamide for severe ANCA-associated vasculitis.

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]]> http://www.nephrologynow.com/publications/rituximab-versus-cyclophosphamide-in-anca-associated-renal-vasculitis/feed 0 Rituximab versus Cyclophosphamide for ANCA-Associated Vasculitis http://www.nephrologynow.com/publications/rituximab-versus-cyclophosphamide-for-anca-associated-vasculitis http://www.nephrologynow.com/publications/rituximab-versus-cyclophosphamide-for-anca-associated-vasculitis#comments Tue, 20 Jul 2010 07:45:22 +0000 Nephrology Now editors http://www.nephrologynow.com/?p=1544 This non-inferiority trial finds that rituximab therapy was not inferior to daily cyclophosphamide treatment for induction of remission in severe ANCA-associated vasculitis and may be superior in relapsing disease. See the associated editorial. Related Articles: Rituximab versus Cyclophosphamide in ANCA-Associated Renal Vasculitis Prolonged disease-free remission following rituximab and low-dose cyclophosphamide therapy for renal ANCA-associated vasculitis [...]]]>
This non-inferiority trial finds that rituximab therapy was not inferior to daily cyclophosphamide treatment for induction of remission in severe ANCA-associated vasculitis and may be superior in relapsing disease.
See the associated editorial.

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]]> http://www.nephrologynow.com/publications/rituximab-versus-cyclophosphamide-for-anca-associated-vasculitis/feed 0 Pulse versus daily oral cyclophosphamide for induction of remission in antineutrophil cytoplasmic antibody—associated vasculitis. http://www.nephrologynow.com/publications/pulse-versus-daily-oral-cyclophosphamide-for-induction-of-remission-in-antineutrophil-cytoplasmic-antibody%e2%80%94associated-vasculitis http://www.nephrologynow.com/publications/pulse-versus-daily-oral-cyclophosphamide-for-induction-of-remission-in-antineutrophil-cytoplasmic-antibody%e2%80%94associated-vasculitis#comments Sat, 02 May 2009 22:24:06 +0000 editor http://www.nephrologynow.com.s65750.gridserver.com/?p=832 This randomized controlled trial compared pulse versus oral cyclophosphamide for induction in ANCA vasculitis. No difference in efficacy was detected between the two arms but pulse treatment resulted in a reduced cumulative cyclophosphamide dose and caused fewer cases of leukopenia. Related Articles: Rituximab versus Cyclophosphamide for ANCA-Associated Vasculitis Mycophenolate mofetil versus cyclophosphamide for induction treatment [...]]]>

This randomized controlled trial compared pulse versus oral cyclophosphamide for induction in ANCA vasculitis. No difference in efficacy was detected between the two arms but pulse treatment resulted in a reduced cumulative cyclophosphamide dose and caused fewer cases of leukopenia.

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]]> http://www.nephrologynow.com/publications/pulse-versus-daily-oral-cyclophosphamide-for-induction-of-remission-in-antineutrophil-cytoplasmic-antibody%e2%80%94associated-vasculitis/feed 0 Vasculitis syndromes: which maintenance therapy for ANCA vasculitis? http://www.nephrologynow.com/publications/vasculitis-syndromes-which-maintenance-therapy-for-anca-vasculitis http://www.nephrologynow.com/publications/vasculitis-syndromes-which-maintenance-therapy-for-anca-vasculitis#comments Fri, 01 May 2009 21:22:25 +0000 Nephrology Now editors http://www.nephrologynow.com.s65750.gridserver.com/publications/vasculitis-syndromes-which-maintenance-therapy-for-anca-vasculitis Related Articles: Prolonged disease-free remission following rituximab and low-dose cyclophosphamide therapy for renal ANCA-associated vasculitis BSR and BHPR guidelines for the management of adults with ANCA associated vasculitis. Mycophenolate mofetil versus cyclophosphamide for inducing remission of ANCA vasculitis with moderate renal involvement.]]> Related Articles: Prolonged disease-free remission following rituximab and low-dose cyclophosphamide therapy for renal ANCA-associated vasculitis BSR and BHPR guidelines for the management of adults with ANCA associated vasculitis. Mycophenolate mofetil versus cyclophosphamide for inducing remission of ANCA vasculitis with moderate renal involvement.]]> http://www.nephrologynow.com/publications/vasculitis-syndromes-which-maintenance-therapy-for-anca-vasculitis/feed 0 Review article: Progress of treatment in ANCA-associated vasculitis. http://www.nephrologynow.com/publications/review-article-progress-of-treatment-in-anca-associated-vasculitis http://www.nephrologynow.com/publications/review-article-progress-of-treatment-in-anca-associated-vasculitis#comments Tue, 30 Nov 1999 05:00:00 +0000 editor http://www.nephrologynow.com.s65750.gridserver.com/publications/review-article-progress-of-treatment-in-anca-associated-vasculitis Related Articles: Vasculitis syndromes: which maintenance therapy for ANCA vasculitis? Treatment of Antineutrophil Cytoplasmic Antibody Associated Vasculitis: A Systematic Review. Review article: New-onset diabetes after transplantation.]]> Related Articles: Vasculitis syndromes: which maintenance therapy for ANCA vasculitis? Treatment of Antineutrophil Cytoplasmic Antibody Associated Vasculitis: A Systematic Review. Review article: New-onset diabetes after transplantation.]]> http://www.nephrologynow.com/publications/review-article-progress-of-treatment-in-anca-associated-vasculitis/feed 0 Outcomes from studies of antineutrophil cytoplasm antibody associated vasculitis: a systematic review by the European League Against Rheumatism systemic vasculitis task force. http://www.nephrologynow.com/publications/outcomes-from-studies-of-antineutrophil-cytoplasm-antibody-associated-vasculitis-a-systematic-review-by-the-european-league-against-rheumatism-systemic-vasculitis-task-force http://www.nephrologynow.com/publications/outcomes-from-studies-of-antineutrophil-cytoplasm-antibody-associated-vasculitis-a-systematic-review-by-the-european-league-against-rheumatism-systemic-vasculitis-task-force#comments Tue, 30 Nov 1999 05:00:00 +0000 editor http://www.nephrologynow.com.s65750.gridserver.com/publications/outcomes-from-studies-of-antineutrophil-cytoplasm-antibody-associated-vasculitis-a-systematic-review-by-the-european-league-against-rheumatism-systemic-vasculitis-task-force Related Articles: Treatment of Antineutrophil Cytoplasmic Antibody Associated Vasculitis: A Systematic Review. Maintenance Immunosuppression in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis Pulse versus daily oral cyclophosphamide for induction of remission in antineutrophil cytoplasmic antibody—associated vasculitis.]]> Related Articles: Treatment of Antineutrophil Cytoplasmic Antibody Associated Vasculitis: A Systematic Review. Maintenance Immunosuppression in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis Pulse versus daily oral cyclophosphamide for induction of remission in antineutrophil cytoplasmic antibody—associated vasculitis.]]> http://www.nephrologynow.com/publications/outcomes-from-studies-of-antineutrophil-cytoplasm-antibody-associated-vasculitis-a-systematic-review-by-the-european-league-against-rheumatism-systemic-vasculitis-task-force/feed 0 Treatment for renal vasculitis and Goodpasture’s disease in adults. http://www.nephrologynow.com/publications/treatment-for-renal-vasculitis-and-goodpastures-disease-in-adults http://www.nephrologynow.com/publications/treatment-for-renal-vasculitis-and-goodpastures-disease-in-adults#comments Tue, 30 Nov 1999 05:00:00 +0000 editor http://www.nephrologynow.com.s65750.gridserver.com/publications/treatment-for-renal-vasculitis-and-goodpastures-disease-in-adults Related Articles: BSR and BHPR guidelines for the management of adults with ANCA associated vasculitis. Recommendations and guidelines for the diagnosis and treatment of Fabry nephropathy in adults. Immunosuppressive treatment for focal segmental glomerulosclerosis in adults.]]> Related Articles: BSR and BHPR guidelines for the management of adults with ANCA associated vasculitis. Recommendations and guidelines for the diagnosis and treatment of Fabry nephropathy in adults. 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Rituximab versus Cyclophosphamide in ANCA-Associated Renal Vasculitis]]> Related Articles: Prolonged disease-free remission following rituximab and low-dose cyclophosphamide therapy for renal ANCA-associated vasculitis Pulse versus daily oral cyclophosphamide for induction of remission in antineutrophil cytoplasmic antibody—associated vasculitis. Rituximab versus Cyclophosphamide in ANCA-Associated Renal Vasculitis]]> http://www.nephrologynow.com/publications/mycophenolate-mofetil-versus-cyclophosphamide-for-inducing-remission-of-anca-vasculitis-with-moderate-renal-involvement/feed 0 Challenges in the management of microscopic polyangiitis: past, present and future. http://www.nephrologynow.com/publications/challenges-in-the-management-of-microscopic-polyangiitis-past-present-and-future http://www.nephrologynow.com/publications/challenges-in-the-management-of-microscopic-polyangiitis-past-present-and-future#comments Tue, 30 Nov 1999 05:00:00 +0000 editor http://www.nephrologynow.com.s65750.gridserver.com/publications/challenges-in-the-management-of-microscopic-polyangiitis-past-present-and-future Related Articles: Urine proteomics: the present and future of measuring urinary protein components in disease. The advantages and challenges of increasing the duration and frequency of maintenance dialysis sessions. Clinical Practice Guidelines for the Diagnosis and Management of Intravascular Catheter‐Related Infection: 2009 Update by the Infectious Diseases Society of America]]> Related Articles: Urine proteomics: the present and future of measuring urinary protein components in disease. The advantages and challenges of increasing the duration and frequency of maintenance dialysis sessions. 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Long-Term Experience With Kidney Transplantation From Hepatitis C-Positive Donors Into Hepatitis C-Positive Recipients Review article: Progress of treatment in ANCA-associated vasculitis.]]> Related Articles: Treatment of early mixed cellular and humoral renal allograft rejection with tacrolimus and mycophenolate mofetil. Long-Term Experience With Kidney Transplantation From Hepatitis C-Positive Donors Into Hepatitis C-Positive Recipients Review article: Progress of treatment in ANCA-associated vasculitis.]]> http://www.nephrologynow.com/publications/treatment-of-hepatitis-c-associated-mixed-cryoglobulinemia-vasculitis/feed 1 BSR and BHPR guidelines for the management of adults with ANCA associated vasculitis. http://www.nephrologynow.com/publications/bsr-and-bhpr-guidelines-for-the-management-of-adults-with-anca-associated-vasculitis http://www.nephrologynow.com/publications/bsr-and-bhpr-guidelines-for-the-management-of-adults-with-anca-associated-vasculitis#comments Tue, 30 Nov 1999 05:00:00 +0000 editor http://www.nephrologynow.com.s65750.gridserver.com/publications/bsr-and-bhpr-guidelines-for-the-management-of-adults-with-anca-associated-vasculitis Related Articles: Recommendations and guidelines for the diagnosis and treatment of Fabry nephropathy in adults. Clinical Practice Guidelines for the Diagnosis and Management of Intravascular Catheter‐Related Infection: 2009 Update by the Infectious Diseases Society of America Vasculitis syndromes: which maintenance therapy for ANCA vasculitis?]]> Related Articles: Recommendations and guidelines for the diagnosis and treatment of Fabry nephropathy in adults. Clinical Practice Guidelines for the Diagnosis and Management of Intravascular Catheter‐Related Infection: 2009 Update by the Infectious Diseases Society of America Vasculitis syndromes: which maintenance therapy for ANCA vasculitis?]]> http://www.nephrologynow.com/publications/bsr-and-bhpr-guidelines-for-the-management-of-adults-with-anca-associated-vasculitis/feed 0 Treatment of Antineutrophil Cytoplasmic Antibody Associated Vasculitis: A Systematic Review. http://www.nephrologynow.com/publications/treatment-of-antineutrophil-cytoplasmic-antibody-associated-vasculitis-a-systematic-review http://www.nephrologynow.com/publications/treatment-of-antineutrophil-cytoplasmic-antibody-associated-vasculitis-a-systematic-review#comments Tue, 30 Nov 1999 05:00:00 +0000 editor http://www.nephrologynow.com.s65750.gridserver.com/publications/treatment-of-antineutrophil-cytoplasmic-antibody-associated-vasculitis-a-systematic-review Related Articles: Outcomes from studies of antineutrophil cytoplasm antibody associated vasculitis: a systematic review by the European League Against Rheumatism systemic vasculitis task force. 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Maintenance Immunosuppression in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis Pulse versus daily oral cyclophosphamide for induction of remission in antineutrophil cytoplasmic antibody—associated vasculitis.]]> http://www.nephrologynow.com/publications/treatment-of-antineutrophil-cytoplasmic-antibody-associated-vasculitis-a-systematic-review/feed 0 Arterial Microaneurysms in Polyarteritis Nodosa. http://www.nephrologynow.com/publications/arterial-microaneurysms-in-polyarteritis-nodosa http://www.nephrologynow.com/publications/arterial-microaneurysms-in-polyarteritis-nodosa#comments Tue, 30 Nov 1999 05:00:00 +0000 editor http://www.nephrologynow.com.s65750.gridserver.com/publications/arterial-microaneurysms-in-polyarteritis-nodosa Related Articles: Calciphylaxis with Arterial Calcification Increases in antihypertensive prescriptions and reductions in cardiovascular events in Canada. 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