November 30, 2015

Comparison of standard and accelerated initiation of renal replacement therapy in acute kidney injury

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This 12-center open-label pilot trial of critically ill adults with volume replete severe AKI randomized atients were randomized to accelerated (12 h or less from eligibility) or standard RRT initiation. The enrollment median serum creatinine was 268 micromoles/l and urine output was 356 ml per 24 h. Clinical outcomes at 90 days included mortality which was 38% in the accelerated and 37% in the standard arm. The feasibility and findings of this study can be used to inform a large-scale effectiveness randomized control trial.

Related Articles:

Acute Kidney Injury, Clinical Nephrology, Clinical Trial Results