October 18, 2009

Effects of valsartan on morbidity and mortality in uncontrolled hypertensive patients with high cardiovascular risks: KYOTO HEART Study

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This trial using a PROBE design compared add-on therapy with an ARB as compared to alternative antihypertensive agents in Japanese patients with uncontrolled hypertension. A reduction in hard clinical endpoints was observed in the Valsartan add-on group.

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  • Giancarlo Ruggieri

    My first concern is according to that of R Jenkins. The second one is the lack of explicantions about the different incidence of brain vascular events of Japanese people versus the others populations, difference on which could possibly be based the best efficacy of ARBS

  • R Jenkins

    An interesting paper which supports the use of ARBs to reduce hard clinical endpoints. My only concern is whether the results of this paper can be generalized beyond Japanese patients.