May 23, 2012

Frequency of HLA-DP-specific antibodies and a possible new cross-reacting group

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Donor specific HLA antibodies to mismatched class II antigens are a common feature of late kidney graft loss. Although antibodies to HLA-DR and -DQ antigens have been recognized for quite some time, antibodies to HLA-DP have an unclear clinical significance. This study examined the incidence of HLA-DP-specific antibodies in 650 patients on the kidney transplant wait list and found a higher prevalence of DP antibodies (42%) than previously reported in smaller studies. Most DP-reactive sera (62%) were from patients with previous transplants. The study highlights cross-reactivity between DP and DR antigens that explains the high frequency of DP reactivity.

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