December 26, 2010

Fungal Peritonitis in Peritoneal Dialysis Patients: Successful Prophylaxis with Fluconazole, as Demonstrated by Prospective Randomized Control Trial

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This randomized controlled trial compared oral fluconazole 200 mg given every 2nd day versus placebo in patients being treated for PD peritonitis, exit site infection or tunnel infection. A statistically significant reduction in secondary fungal peritonitis was noted in patients on prophylaxis.

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Peritoneal Dialysis
  • Oxoproline

    Possibly, but the course is only 2-3 weeks during antibiotic treatment, not indefinite exposure, so I’d think the risk would be lower.

  • Guest

    Wouldn’t resistance to fluconazole become an issue?

  • Oxoproline

    NNT = 20, should be a valuable intervention.