February 15, 2013

High-Efficiency Postdilution Online Hemodiafiltration Reduces All-Cause Mortality in Hemodialysis Patients

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This multicenter, open-label, randomized controlled trial randomized chronic hemodialysis patients to conventional hemodialysis or high-efficiency postdilution online hemodiafiltration (OL-HDF).

Patients assigned to OL-HDF had a 30% lower risk of all-cause mortality compared to those on conventional hemodialysis (hazard ratio [HR], 0.70; 95% confidence interval [95% CI], 0.53–0.92; P=0.01).  In addition, the OL-HDF group had a 33% lower risk of cardiovascular mortality (HR, 0.67; 95% CI, 0.44–1.02; P=0.06) and a 55% lower risk of infection-related mortality (HR, 0.45; 95% CI, 0.21–0.96; P=0.03).


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