November 12, 2011

Intensive Diabetes Therapy and Glomerular Filtration Rate in Type 1 Diabetes

This paper was published online in the New England Journal of Medicine paper in order to coincide with the oral presentation at the 2011 American Society of Nephrology meeting.

This report describes renal follow-up of Type 1 diabetic patients enrolled in the DCCT (Diabetes Control and Complications Trial) and EDIC (Epidemiology of Diabetes Interventions and Complications) studies. The study showed a decrease in the risk of decline in eGFR to < 60 ml/min (as measured by the CKD-EPI equation) in the group that received intensive diabetes therapy versus those that received conventional diabetes therapy.  There was a trend (p =0.10) to reduced incidence of end-stage renal disease in the intensive therapy group.  The benefits of intensive therapy persisted after adjustments were made for glycated hemoglobin and albumin excretion.

Free full text available courtesy of the New England Journal of Medicine for a short time.

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Clinical Trial Results, Diabetes

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