July 14, 2013

Mycophenolate Mofetil or Intravenous Cyclophosphamide for Lupus Nephritis With Poor Kidney Function: A Subgroup Analysis of the Aspreva Lupus Management Study

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This post hoc subgroup analysis of the ALMS trial (comparing MMF to cyclophosphamide in lupus nephritis) specifically assessed patients with GFR < 30 ml/min/1.73m2. No difference was detected in the primary outcome of response to treatment (decrease in proteinuria and stabilization or improvement of serum creatinine level). The accompanying editorial asks whether post-hoc subgroup analyses should change treatment patterns: https://readbyqxmd.com/read/23582251/mycophenolate-mofetil-in-severe-lupus-nephritis-should-post-hoc-analyses-change-treatment-patterns

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