May 1, 2017

Obesity increases the risk of end-stage renal disease among living kidney donors

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This study looked at the risk of ESRD associated with obesity at the time of donation among 119 769 live kidney donors in the United States with a maximum follow-up was 20 years. The estimated risk of ESRD 20 years after donation was 93.9 per 10 000 for obese; significantly greater than the 39.7 per 10 000 for non-obese live kidney donors. When adjusted for age, sex, ethnicity, blood pressure, baseline estimated glomerular filtration rate, and relationship to recipient, obese live kidney donors had a significant 86% increased risk of ESRD compared to their non-obese counterparts (adjusted hazard ratio 1.86; 95% confidence interval 1.05–3.30). Furthermore, for each unit increase in BMI above 27 kg/m2 there was an associated significant 7% increase in ESRD risk (1.07, 1.02–1.12).






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Chronic Kidney Disease, General Nephrology, Renal Transplantation