August 14, 2016

Past Decline Versus Current eGFR and Subsequent ESRD Risk

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This CKD Prognosis Consortium study examined 22 cohorts to determine the association of past slopes and current eGFR level with subsequent ESRD.  5163 ESRD events were recorded in the 1,080,223 participants during a mean follow-up of 2.0 years. The results showed that current eGFR [30 versus 50 ml/min per 1.73 m(2) (a difference of 20 ml/min per 1.73 m(2)) associated with an adjusted hazard ratio of 19.9 (95% confidence interval, 13.6 to 29.1)] was more strongly associated with future ESRD risk than the magnitude of past eGFR decline [a slope of -6 versus 0 ml/min per 1.73 m(2) per year over the previous 3 years (a decline of 18 ml/min per 1.73 m(2) versus no decline) associated with an adjusted hazard ratio of ESRD of 2.28 (95% confidence interval, 1.88 to 2.76)], but both contributed substantially to the risk of ESRD, especially at eGFR<30 ml/min per 1.73 m(2).

 

 

 

 

 

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