November 16, 2014

Perioperative Aspirin and Clonidine and Risk of Acute Kidney Injury

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In this sub-study of the POISE-2 study, neither ASA or clonidine reduced the risk of acute kidney injury after non-cardiac surgery.

Of note, aspirin increased the risk of major bleeding (which was associated with a greater risk of acute kidney injury).  As well, clonidine increased the risk of clinically important hypotension (which was associated with a greater risk of acute kidney injury).

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Acute Kidney Injury