In this sub-study of the POISE-2 study, neither ASA or clonidine reduced the risk of acute kidney injury after non-cardiac surgery.
Of note, aspirin increased the risk of major bleeding (which was associated with a greater risk of acute kidney injury). As well, clonidine increased the risk of clinically important hypotension (which was associated with a greater risk of acute kidney injury).
- A new model to predict acute kidney injury requiring renal replacement therapy after cardiac surgery
- Stroke and Bleeding in Atrial Fibrillation with Chronic Kidney Disease
- Effect of Remote Ischemic Preconditioning on Kidney Injury Among High-Risk Patients Undergoing Cardiac Surgery A Randomized Clinical Trial