November 29, 2011
This study of twenty-three patients presenting or relapsing with ANCA-associated vasculitis were treated with two pulses of rituximab 2 weeks apart, six biweekly doses of cyclophosphamide and a tapering course of oral steroids. They were subsequently put on a maintenance regimen of low-dose steroids and azathioprine. All patients achieved clinical remission within six weeks. Five patients relapsed at a median of 30 months. Adverse events included one severe drug reaction and one serious infection. This regimen may be considered in the creation of steroid minimizing regimen.