November 29, 2011

Prolonged disease-free remission following rituximab and low-dose cyclophosphamide therapy for renal ANCA-associated vasculitis

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This study of twenty-three patients presenting or relapsing with ANCA-associated vasculitis were treated with two pulses of rituximab 2 weeks apart, six biweekly doses of cyclophosphamide and a tapering course of oral steroids. They were subsequently put on a maintenance regimen of low-dose steroids and azathioprine.  All patients achieved clinical remission within six weeks. Five patients relapsed at a median of 30 months.  Adverse events included one severe drug reaction and one serious infection.  This regimen may be considered in the creation of steroid minimizing regimen.

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