February 26, 2012

Randomized Controlled Trial Comparing Mupirocin and Polysporin Triple Ointments in Peritoneal Dialysis Patients: The MP3 Study

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This double-blind multicentre RCT studied the effectiveness of topical Polysporin Triple ointment as compared to mupirocin to peritoneal dialysis catheter exit sites.  Twice the number of patients experienced redness at the exit site in the Polysporin Triple group (14 versus 6, P=0.10) with a higher rate of fungal exit site infection (0.07 versus 0.01; P=0.02)  and peritonitis (0.04 versus 0.00, respectively; P<0.05). The authors suggest that Polysporin Triple should not be used for prophylaxis of PD-related infections.

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