September 21, 2015

Randomized Trial of Bicarbonate or Saline Study for the Prevention of Contrast-Induced Nephropathy in Patients with CKD

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Sodium bicarbonate vs sodium chloride has always plagued those of us trying to prevent acute contrast nephropathy.  This prospective, double-blind, multicenter randomized clinical trial of 391 with eGFR < 45 ml/min were randomized to either infusion.  There was no difference in the primary composite outcome of mortality, dialysis, or a sustained 20% reduction in eGFR at 6 months between the two groups.  Furthermore, there was also no difference in the incidence of acute contrast nephropathy between the treatment groups (14.5% versus 12.1%, respectively; P=0.20).

Related Articles:

Acute Kidney Injury, Clinical Nephrology, Contrast Nephropathy