February 26, 2012

Recurrent Dense Deposit Disease After Renal Transplantation: An Emerging Role for Complementary Therapies

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Membranoproliferative glomerulonephritis type II, or dense deposit disease, is a rare type of renal disease caused by excessive complement deposition in the kidney. It is also associated with a high rate of recurrence post-transplant. In this case report, a patient developed recurrent dense deposit disease shortly after transplant. Despite aggressive treatment, renal function worsened and proteinuria increased. Starting treatment with eculizumab, a monoclonal antibody that blocks complement activation, led to improved renal function and decreased proteinuria. This suggests a role for complement inhibition in both native and recurrent dense deposit disease.

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