November 19, 2016

Remote ischaemic preconditioning (RIPC) leads to sustained improvement in allograft function following live donor (LD) kidney transplantation: 5 year follow up in the REnal Protection Against Ischaemia Reperfusion in transplantation (REPAIR) study

ASN 2016 High Impact Clinical Trial

Kristin Veighey, Jennifer Nicholas, Tim Clayton, Raymond Macallister

Using 4 cycles of ischemia/reperfusion in the preoperative living donors, remote ischemic preconditioning (RIPC) was evaluated regarding its impact on post-tranplant outcomes.  The primary endpoint was iohexal GFR at 12 months and secondary endpoints were change in eGFR, graft loss or death.  There was no difference in the primary outcome.  At 5 years post-transplantation, in the early RIPC group vs control, there was an overall improvement in eGFR by 4.8 ml/min (p = 0.003).  There was no impact in the late RIPC or dual RIPC groups.

 

 

 

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