Remote ischaemic preconditioning (RIPC) leads to sustained improvement in allograft function following live donor (LD) kidney transplantation: 5 year follow up in the REnal Protection Against Ischaemia Reperfusion in transplantation (REPAIR) study
ASN 2016 High Impact Clinical Trial
Kristin Veighey, Jennifer Nicholas, Tim Clayton, Raymond Macallister
Using 4 cycles of ischemia/reperfusion in the preoperative living donors, remote ischemic preconditioning (RIPC) was evaluated regarding its impact on post-tranplant outcomes. The primary endpoint was iohexal GFR at 12 months and secondary endpoints were change in eGFR, graft loss or death. There was no difference in the primary outcome. At 5 years post-transplantation, in the early RIPC group vs control, there was an overall improvement in eGFR by 4.8 ml/min (p = 0.003). There was no impact in the late RIPC or dual RIPC groups.
- Effect of Remote Ischemic Preconditioning on Kidney Injury Among High-Risk Patients Undergoing Cardiac Surgery A Randomized Clinical Trial
- Effect of Obesity on the Outcome of Kidney Transplantation: A 20-Year Follow-Up
- HLA-Specific Antibodies Developed in the First Year Posttransplant are Predictive of Chronic Rejection and Renal Graft Loss