Sodium Bicarbonate for the Prevention of Contrast Induced-Acute Kidney Injury: A Systematic Review and Meta-analysis
This meta-analysis examined the use of sodium bicarbonate vs sodium chloride for the prevention of contrast induced nephropathy. The authors detected significant heterogeneity that was largely explained by trial size and publication status. Among the large randomized trials, there was no benefit for hydration with sodium bicarbonate. Studies suggesting a benefit of sodium bicarbonate was limited to small trials of lower methodological quality.
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