Sodium Bicarbonate Plus Isotonic Saline Versus Saline for Prevention of Contrast-Induced Nephropathy in Patients Undergoing Coronary Angiography: A Randomized Controlled Trial
This randomized double-blind trial compares the combination of sodium bicarbonate and isotonic saline with that of isotonic saline alone in preventing contrast-induced nephropathy (CIN). Of the 256 patients randomized, nine patients (7.4%) receiving sodium bicarbonate developed CIN as opposed to 7 patients (5.9%) in the saline group, which was not statistically different. The authors conclude that there was no overall benefit to sodium bicarbonate in the prevention of CIN.
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- Randomized Trial of Bicarbonate or Saline Study for the Prevention of Contrast-Induced Nephropathy in Patients with CKD