September 27, 2010

Steroid Pretreatment of Organ Donors to Prevent Postischemic Renal Allograft Failure A Randomized, Controlled Trial

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Steroids are frequently given to neurologically-deceased donors prior to organ procurement. They may also prevent an inflammatory response in the kidney, which is known to play a role in the development of delayed graft function post-transplant. This blinded, randomized controlled trial compared steroid treatment to placebo. Although markers of inflammation were suppressed, steroids did not change the rate of delayed graft function or renal function in the early post-transplant period.

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Renal Transplantation
  • So it turns out that the steroids are not doing anything? What are the effects to the transplantee?