Posts Tagged ‘immunology’

May 23, 2012

Durability of Antibody Removal Following Proteasome Inhibitor-Based Therapy

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Experience with proteasome inhibitors (PI) for treating antibody-mediated rejection (ABMR) and HLA antibody removal is increasing. However, the durability of the effects PI on HLA antibody removal is unknown. This study examines this question from a unique point of view due to the use of the PI bortezomib as either a combination therapy or a […]

Comments Off on Durability of Antibody Removal Following Proteasome Inhibitor-Based Therapy Posted in Renal Transplantation
May 23, 2012

Pretransplant Donor-Specific HLA Class-I and -II Antibodies Are Associated with an Increased Risk for Kidney Graft Failure

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The recent development of Luminex reagents capable of detecting complement fixing HLA antibodies has sparked a lot of interest in the best way to apply this information. This study examined C1Q-fixing HLA antibodies in a retrospective study of pre-transplant samples in patients transplanted across a negative cytotoxic cross-match. Of the 837 sera examined, 210 contained […]

Comments Off on Pretransplant Donor-Specific HLA Class-I and -II Antibodies Are Associated with an Increased Risk for Kidney Graft Failure Posted in Renal Transplantation
May 23, 2012

Frequency of HLA-DP-specific antibodies and a possible new cross-reacting group

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Donor specific HLA antibodies to mismatched class II antigens are a common feature of late kidney graft loss. Although antibodies to HLA-DR and -DQ antigens have been recognized for quite some time, antibodies to HLA-DP have an unclear clinical significance. This study examined the incidence of HLA-DP-specific antibodies in 650 patients on the kidney transplant […]

Comments Off on Frequency of HLA-DP-specific antibodies and a possible new cross-reacting group Posted in Renal Transplantation