July 10, 2009

The Hannover Dialysis Outcome study: comparison of standard versus intensified extended dialysis for treatment of patients with acute kidney injury in the intensive care unit

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This prospective randomized parallel group trial aimed to assess mortality and renal recovery of patients with acute kidney injury (AKI) receiving either standard (SED) or intensified extended dialysis (IED) therapy in the intensive care unit. 156 patients with AKI were randomly assigned to receive standard dialysis or intensified dialysis. No differences between intensified and standard treatment were seen for survival by Day 14 or for renal recovery amongst the survivors by Day 28. These results support the findings of other recent studies which suggest that increasing dialysis dose in the ICU has limited clinical efficacy.

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Acute Kidney Injury, Critical Care

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