The time course of peritoneal transport parameters in peritoneal dialysis patients who develop encapsulating peritoneal sclerosis.
This single centre retrospective cohort study examined longitudinal changes in small solute transport and other peritoneal membrane characteristics of 12 patients prior to the development of encapsulating peritoneal sclerosis (EPS) compared to 21 vintage-matched controls who did not develop EPS but did develop peritoneal ultrafiltration failure. No differences in the time course of small solute transport characteristics or peritoneal ultrafiltration capacity was seen between the two groups. The authors conclude that early functional peritoneal membrane changes alone cannot delineate between patients who develop simple ultrafiltration failure vs those destined to develop EPS.
This suggests that routine monitoring of peritoneal membrane function does not have a role in the early detection of EPS.
- Effect of Neutral-pH, Low–Glucose Degradation Product Peritoneal Dialysis Solutions on Residual Renal Function, Urine Volume, and Ultrafiltration: A Systematic Review and Meta-Analysis
- Screening for encapsulating peritoneal sclerosis in patients on peritoneal dialysis: role of CT scanning.
- Tamoxifen is associated with lower mortality of encapsulating peritoneal sclerosis: results of the Dutch Multicentre EPS Study