September 13, 2009

Ticagrelor versus Clopidogrel in Patients with Acute Coronary Syndromes

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This randomized controlled trial compared two different strategies of platelet inhibition in acute coronary syndrome with either clopidogrel or ticagrelor. This study may be of some relevance to nephrologists give the higher incidence of cardiovascular events in patient with renal insufficiency. While outcomes were better with ticagrelor, Nephrologists may be interested to know that renal function 12 months after the ACS had declined by 11% in the ticagrelor group vs 9% in those on clopidogrel (p<0.001). Individual practitioners will need to decide if this is clinically significant.

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