July 13, 2015

Treatment With Multiple Blood Pressure Medications, Achieved Blood Pressure, and Mortality in Older Nursing Home Residents The PARTAGE Study

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This longitudinal study of nursing home residents > 80 years of age showed a significant in interaction with <130 mmHg SBP and use of 2 more blood pressure lowering agents.  There was a comparatively higher risk of mortality (unadjusted hazard ratio [HR], 1.81; 95% CI, 1.36-2.41); adjusted HR, 1.78; 95% CI, 1.34-2.37; both P < .001) in these patients.  Three sensitivity analysis (propensity score-matched subsets, adjustment for cardiovascular comorbidities and exclusion of patients without hypertension on BP lowering agents) confirmed this excess risk.  This study raises a cautionary note on “excess lowering” of blood pressure in this population.




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