March 18, 2015

Trimethoprim-sulfamethoxazole and risk of sudden death among patients taking spironolactone

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Compared with amoxicillin, trimethoprim-sulfamethoxazole was associated with a  twofold increase of sudden death (adjusted OR 2.46, 95 % CI 1.55-3.90) as a consequence of hyperkalemia in this population-based study of patients over the age of 65 on spironolactone.

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