This randomized controlled trial compared ultrafiltration versus stepped pharmacologic therapy in patients with acute decompensated heart failure and a decline in kidney function (cardiorenal syndrome). Ultrafiltration was found to be inferior in achieving the bivariate endpoint in change in serum creatinine and body weight after 96 hours. The ultrafiltration group experienced a higher rate of serious adverse events (72% vs 57%, p=0.03).
- Decongestive Treatment of Acute Decompensated Heart Failure: Cardiorenal Implications of Ultrafiltration and Diuretics
- Diuretic Strategies in Patients with Acute Decompensated Heart Failure
- Intensive vs Standard Blood Pressure Control and Cardiovascular Disease Outcomes in Adults Aged ≥75Years: A Randomized Clinical Trial