NephrologyNow The Ultimate Guide to Kidney Disease Research

May 1, 2010

Vitamins C and E to Prevent Complications of Pregnancy-Associated Hypertension

Roberts JM, Myatt L, Spong CY, Thom EA, Hauth JC, Leveno KJ, Pearson GD, Wapner RJ, Varner MW, Thorp JM Jr, Mercer BM, Peaceman AM, Ramin SM, Carpenter MW, Samuels P, Sciscione A, Harper M, Smith WJ, Saade G, Sorokin Y, Anderson GB, Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. N Engl J Med. 2010 Apr 8;362(14):1282-91

This multicenter, randomized, double-blind trial randomized low risk nulliparous women to daily supplementation with vitamin C and vitamin E or placebo early in pregnancy. The study failed to reduce the primary outcome of severe pregnancy-associated hypertension alone or severe/mild hypertension with elevated liver-enzyme levels, thrombocytopenia, elevated serum creatinine levels, eclamptic seizure, medically indicated preterm birth, fetal-growth restriction, or perinatal death.